The Effects of Chronic Preoperative Opioid Use on Single-level Lumbar Fusion Outcomes.

Clinical Spine Surgery : a Spine Publication
Sarah BhattacharjeeMichael J Lee

Abstract

A retrospective study using a national insurance claims database. The objective of this study was to assess the relationship between chronic preoperative opioids and the outcomes of revision surgery and nonunion after single-level lumbar fusion. Opioids are widely utilized for pain management before spine procedures. Studies have associated opioids with unfavorable postoperative outcomes, and animal models have also linked opioid administration with unstable bone healing. Single-level lumbar fusion patients were identified. Patients with any fracture history within 1 year before surgery were excluded. A chronic preoperative opioid cohort was defined by opioids prescriptions within 3 months prior and within 4-6 months before surgery. The rates of revision surgery within 6 months and nonunion within 6-24 months after surgery were assessed. Univariate analyses of chronic preoperative opioid prescriptions and various comorbidities for revision and nonunion were conducted followed by multivariate analyses controlling for these factors. Individual analyses were run for each of the 3 single-level lumbar fusion procedures. A total of 8494 single-level lumbar fusion patients were identified. Of the 3929 (46.3%) patients filled criteria ...Continue Reading

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Citations

Jul 26, 2021·Clinical Neurology and Neurosurgery·Charbel MoussalemIbrahim Omeis

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