The effects of chronic testosterone administration on body weight, food intake, and adipose tissue are changed by estrogen treatment in female rats

Hormones and Behavior
Takeshi IwasaMinoru Irahara

Abstract

In females, estrogens play pivotal roles in preventing excess body weight (BW) gain. On the other hand, the roles of androgens in female BW, appetite, and energy metabolism have not been fully examined. We hypothesized that androgens' effects on food intake (FI) and BW regulation change according to the estrogens' levels. To evaluate this hypothesis, the effects of chronic testosterone administration in ovariectomized (OVX) female rats with or without estradiol supplementation were examined in this study. Chronic testosterone administration decreased BW, FI, white adipose tissue (WAT) weight, and adipocyte size in OVX rats, whereas it increased BW, WAT weight, and adipocyte size in OVX with estradiol-administered rats. In addition, chronic testosterone administration increased hypothalamic CYP19a1 mRNA levels in OVX rats, whereas it did not alter CYP19a1 mRNA levels in OVX with estradiol-administered rats, indicating that conversion of testosterone to estrogens in the hypothalamus may be activated in testosterone-administered OVX rats. Furthermore, chronic testosterone administration decreased hypothalamic TNF-α mRNA levels in OVX rats, whereas it increased hypothalamic IL-1β mRNA levels in OVX with estradiol-administered rats....Continue Reading

Citations

Dec 1, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Takeshi IwasaMinoru Irahara
Jul 22, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Takeshi IwasaMinoru Irahara
Dec 25, 2019·International Journal of Endocrinology·Mahmoud Mustafa Ali AbulmeatySuhail Razak
Dec 31, 2020·Clinical Therapeutics·Kristen M CulbertKelly L Klump
Nov 12, 2021·The Journal of Medical Investigation : JMI·Takeshi IwasaMinoru Irahara

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