The effects of cilazapril alone and in combination with frusemide in healthy subjects

British Journal of Clinical Pharmacology
G D Johnston, A P Passmore

Abstract

1. In a fourway double-blind placebo controlled study, the effects of cilazapril, a new angiotensin converting enzyme inhibitor, on renal function and the responses to intravenous frusemide were studied in a group of twelve salt depleted male volunteers. 2. Cilazapril produced an increase in effective renal plasma flow and urinary output of prostaglandin E2 metabolite (PGE2-M) but no effect on sodium, potassium or water excretion. 3. Pretreatment with cilazapril antagonised the effects of frusemide on glomerular filtration, PGE2-M and sodium excretion.

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Citations

Jan 5, 2002·Journal of Clinical Pharmacology·H UdermanW C Liao
May 21, 2005·Drugs & Aging·David J Goldstein, Dennis C Turk
Dec 26, 1989·The American Journal of Medicine·C H KleinbloesemU W Wiegand
Feb 26, 2016·American Journal of Physiology. Renal Physiology·Xiaohua HuangBranko Braam

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