The effects of cilazapril alone and in combination with frusemide in healthy subjects

British Journal of Clinical Pharmacology
G D Johnston, A P Passmore


1. In a fourway double-blind placebo controlled study, the effects of cilazapril, a new angiotensin converting enzyme inhibitor, on renal function and the responses to intravenous frusemide were studied in a group of twelve salt depleted male volunteers. 2. Cilazapril produced an increase in effective renal plasma flow and urinary output of prostaglandin E2 metabolite (PGE2-M) but no effect on sodium, potassium or water excretion. 3. Pretreatment with cilazapril antagonised the effects of frusemide on glomerular filtration, PGE2-M and sodium excretion.


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Aug 1, 1981·Kidney International·N K HollenbergD P Harrington
Mar 14, 1964·JAMA : the Journal of the American Medical Association·R D WAGONERJ C HUNT

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