The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study

The Journal of Sexual Medicine
Bruno MadeoVincenzo Rochira

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are known to induce delayed orgasm and delayed ejaculation, while their effect on other aspects of sexual function, such as sexual motivation, arousal, and erectile function are unclear. In order to evaluate the effect of chronic administration of two SSRIs, citalopram and fluoxetine, on normal sexual function, we studied the parameters of male sexual behavior, erectile function, and ejaculation on 48 healthy male volunteers, aged 29.5 +/- 4.9, in a randomized, placebo-controlled, double-blind, double-dummy study. Methods. The subjects were randomized to receive placebo (16 subjects), or fluoxetine (20 mg/day) (16 subjects) or citalopram (20 mg/day) for the first week, and 40 mg/day in the following 3 weeks (16 subjects). Sexual function was investigated at the screening and at the end of the study by means of test of penile erection (TPE) and masturbation ejaculation latency time (MELT) performed during visual erotic stimulation, and at each visit by self-filled questionnaires (International Index Erectile Function [IIEF-15] and Golombock Rust Inventory of Sexual Satisfaction [GRISS]). All the erectile parameters, evaluated by means of RigiScan Plus during TPE, were not significa...Continue Reading

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Citations

Oct 1, 2014·Sexual Medicine Reviews·Daniel H Shin, Aaron Spitz
Sep 8, 2009·The Journal of Sexual Medicine·Liliana Dell'OssoMario Maggi
Apr 24, 2010·The Journal of Sexual Medicine·Cheryl A Frye, Madeline E Rhodes
Jul 7, 2009·The Journal of Sexual Medicine·Emmanuele A JanniniIrwin Goldstein
Oct 30, 2010·The Journal of Sexual Medicine·Arthur L BurnettZhong C Xin
Mar 25, 2014·Alimentary Pharmacology & Therapeutics·A O'TooleS Friedman
Apr 2, 2014·Postgraduate Medicine·Anita H ClaytonLata Handiwala
Jan 20, 2018·European Journal of Gastroenterology & Hepatology·Mariangela AlloccaSilvio Danese
Feb 6, 2020·The American Journal of Gastroenterology·Muhammad B Hammami, Uma Mahadevan
Jan 22, 2010·Nordic Journal of Psychiatry·Ulla Knorr, Lars Vedel Kessing
Sep 12, 2019·Frontiers in Behavioral Neuroscience·Olivia Le Moëne, Anders Ågmo

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