The effects of classic ketogenic diet on serum lipid profile in children with refractory seizures

Acta neurologica Belgica
Gholam Reza ZamaniReza Azizi Malamiri

Abstract

More than 25 % of children with epilepsy develop refractory seizures unresponsive to both old and new generation anticonvulsants. Since such seizures have a serious negative impact on the quality of life, other treatment options are considered. The ketogenic diet is a well-known treatment for managing refractory seizures, although its mechanism of action is unknown. Studies have shown that this diet is as good as, or better than, any of the newer medications in reducing seizure frequency. However, concerns about adverse effects have been raised. We conducted an open label trial to show the effects of this diet on serum lipid profile. Thirty-three children with refractory epilepsy were treated with the ketogenic diet and were followed for 6 months. Their serum lipid profile was assessed at baseline, and at 3 and 6 months after initiating the diet. Seizure frequency was reduced in 63 % of children (no seizures in 2/33 and reduced >50 % in 19/33). However, after 6 months of administering the diet, median triglyceride was significantly increased (from 84 to 180 mg/dl, P < 0.001), median total cholesterol was significantly increased (from 180 to 285 mg/dl, P < 0.001), median serum low-density lipoprotein (LDL) was significantly incr...Continue Reading

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Citations

May 16, 2018·Journal of Breath Research·Veronika RuzsányiMatthias Baumann
Jan 26, 2018·Acta neurologica Belgica·Shahabeddin RezaeiMaryam Mahmoudi
Feb 9, 2020·The International Journal of Neuropsychopharmacology·Gerwyn MorrisLisa Olive
Jul 11, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mikiko WatanabeLucio Gnessi
Jul 16, 2017·Scientific Reports·Glenn DalléracNathalie Rouach
Jun 27, 2019·Nutritional Neuroscience·Mohammad BarzegarSina Raeisi
Jun 21, 2021·Seizure : the Journal of the British Epilepsy Association·Ünsal YılmazAycan Ünalp

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