The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability

British Journal of Clinical Pharmacology
I Hindmarch, A C Gudgeon

Abstract

1 Laboratory tests of psychomotor performance and 'on road' assessments of car handling ability were made following repeated doses of clobazam 10 mg three times daily, lorazepam 1 mg three times daily and matching placebo 1 capsule three times daily. 2 Both active compounds produced on impairment, compared to placebo, in some mental arithmetic and letter cancellation tasks, but these effects were neither widespread nor consistent. 3 Lorazepam produced a significant impairment of car driving tasks and analogue rating scales of subjective alertness. The pronounced sedative activity of the drug was also shown in the verbal reports of side effects and in indices of early morning sedation derived from the Leeds Sleep Evaluation Questionnaire. 4 Clobazam did not produce either the objective, or the subjective impairment of performance and alertness found with lorazepam. 5 The results taken as a whole show important differences between the 1,4 benzodiazepine, lorazepam, and the 1,5 benzodiazepine, clobazam, in their effects on the integrity of psychomotor performance related to car driving ability.

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Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·Z Subhan, I Hindmarch
Jan 1, 1985·European Journal of Clinical Pharmacology·Z Subhan, I Hindmarch
Oct 1, 1982·European Journal of Clinical Pharmacology·A C ParrottP D Stonier
Jan 1, 1986·European Journal of Clinical Pharmacology·Z SubhanI Hindmarch
Jan 1, 1982·European Journal of Clinical Pharmacology·I Hindmarch, A C Gudgeon
Jan 1, 1987·European Journal of Clinical Pharmacology·A PatatM Hucher
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·D B FairweatherI Hindmarch
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·P T QuinlanD C O'Brien
May 2, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Fran Ridout, Ian Hindmarch
May 1, 2002·Clinical Neuropharmacology·Joëlle MicallefOlivier Blin
Jul 1, 1991·British Journal of Clinical Pharmacology·C AlfordI Hindmarch
Aug 1, 1995·British Journal of Clinical Pharmacology·D B FairweatherI Hindmarch
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·P CrawfordD Chadwick
Apr 1, 1996·Environmental Health Perspectives·A Wetherell
Feb 9, 2010·Pharmacology & Therapeutics·Anne GierschPierre Vidailhet
Jul 1, 2009·Human Psychopharmacology·Christopher J EdgarKeith A Wesnes
May 7, 2011·Drug and Alcohol Review·Stefanie Y Leung
Nov 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Z Bhatti, I Hindmarch
Jul 1, 1985·British Journal of Clinical Pharmacology·A Patat, P Foulhoux
Sep 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch
Aug 1, 1987·British Journal of Addiction·S D Ferrara
Aug 30, 2016·Accident; Analysis and Prevention·Toni M RudisillBrandon R Rudisill
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I HindmarchS Kimber

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