The effects of clonidine on symptoms and anorectal sensorimotor function in women with faecal incontinence.

Alimentary Pharmacology & Therapeutics
A E BharuchaA R Zinsmeister

Abstract

Women with faecal incontinence and rectal urgency have increased rectal stiffness and sensation. To evaluate the effects of clonidine, an alpha(2) -adrenergic agonist, in faecal incontinence. In this open-label uncontrolled study, bowel symptoms and anorectal functions (anal pressures, rectal compliance, and sensation) were assessed before and during treatment with transdermal clonidine (0.2 mg daily, 4 weeks) in 12 women with urge-predominant faecal incontinence. Clonidine reduced the frequency (17.8 +/- 3.1 before vs. 8.8 +/- 3.9 after, P = 0.03) and number of days with faecal incontinence (11.8 +/- 1.6 before vs. 6.1 +/- 1.8 after, P = 0.02), faecal incontinence symptom severity score (max = 13, 8.3 +/- 0.7 vs. 5.6 +/- 0.9, P < 0.01), and allowed patients to defer defecation for a longer duration (P = 0.03). Although overall effects on anorectal functions were not significant, the treatment-associated reduction in faecal incontinence episodes was associated with increased rectal compliance (r = -0.58, P < 0.05) and reduced rectal sensation. (r = -0.73, P = 0.007 vs. desire to defecate pressure threshold). Clonidine improves symptoms in women with faecal incontinence; this improvement is associated with increased rectal compl...Continue Reading

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Citations

May 4, 2011·Current Gastroenterology Reports·Adil E Bharucha
May 12, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adil E BharuchaAlan R Zinsmeister
Apr 16, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adil E BharuchaAlan R Zinsmeister
Oct 30, 2012·Journal of Neurogastroenterology and Motility·Rebecca E Burgell, S Mark Scott
Oct 1, 2014·Current Treatment Options in Gastroenterology·David Prichard, Adil E Bharucha
Nov 12, 2013·Gastroenterology·Adil E Bharucha, Satish S C Rao
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Adil E BharuchaAlan R Zinsmeister
Feb 24, 2015·Frontiers in Medicine·Yeong Yeh Lee
Jul 18, 2014·World Journal of Gastrointestinal Endoscopy·Haris PapafragkakisSury Anand
Jun 2, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M SharmaA E Bharucha

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