The effects of clozapine on quinpirole-induced non-regulatory drinking and prepulse inhibition disruption in rats.

Psychopharmacology
Lorenza De CarolisPaolo Nencini

Abstract

The biological underpinnings of schizophrenic polydipsia are poorly understood. This study is aimed at fulfilling the requisites of an experimental model of this syndrome through the quinpirole (QNP) induction of non-regulatory drinking in rats. In a first experiment, clozapine (10 and 40 mg/kg p.o.) was substituted for haloperidol during the last 5 days of 10 days QNP (0.5 mg/kg i.p.) administration and water intake measured at 5 h. In a second experiment, animals treated with QNP alone or in combination with clozapine were assessed for water intake and prepulse inhibition (PPI). Expression of genes coding for the dopaminergic D2 receptor, as well as for the early genes BDNF (brain-derived neurotrophic factor) and c-Fos in prefrontal cortex, hippocampus, and striatum was also evaluated. Clozapine prevented QNP-induced drinking at 10 and 40 mg/kg, but only at 40 mg/kg when it was substituted for haloperidol. In the second experiment, QNP-treated rats showed both non-regulatory drinking and PPI disruption. Both these effects were prevented by clozapine 40 mg/kg. QNP-reduced BDNF expression in the hippocampus and increased c-Fos in the prefrontal cortex. This effect was prevented by clozapine. Given by itself, clozapine reduced t...Continue Reading

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May 15, 2012·Pharmacology, Biochemistry, and Behavior·Katherine M SerafineAnthony L Riley
Jul 6, 2014·Schizophrenia Research·Morris B Goldman
Nov 3, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Agata Casado-SainzMikael Palner

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