The effects of cognitive behavioral therapy on resting-state functional brain network in drug-naive patients with obsessive-compulsive disorder

Brain and Behavior
Ping LiZhanjiang Li

Abstract

Although cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD), the treatment mechanisms remain poorly understood. This study aimed to investigate the effects of CBT on changes in the intrinsic whole-brain functional network of OCD patients. Twenty drug-naive and noncomorbid OCD patients were recruited, and resting-state functional magnetic resonance imaging was performed before and after 12 weeks of CBT. Moreover, 20 healthy controls were scanned twice with a 12-week interval. A graph-theory degree centrality (DC) approach and functional connectivity method were used to analyze the whole-brain functional network hub and connectivity changes in OCD patients before and after CBT treatment. A significant group × time interaction on DC was found in the left dorsolateral prefrontal cortex (DLPFC); the DC in the left DLPFC was significantly reduced after CBT treatment. Resting-state functional connectivity (RSFC) between the left DLPFC and right orbitofrontal cortex was increased in the OCD patients at baseline, and normalized after CBT treatment. RSFC changes between the left DLPFC and default mode network (DMN) positively correlated with changes in clinical symptoms in OCD patients. T...Continue Reading

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Citations

Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·David PagliaccioRachel Marsh
Jan 2, 2021·The American Journal of Psychiatry·Wayne K GoodmanSameer A Sheth
Jul 20, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ruixiang CaoZhanjiang Li
Apr 18, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Anders L ThorsenOdile A van den Heuvel

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