The effects of colchicine and vinblastine on memory in chicks

Behavioural Brain Research
G A Bell, I G Morgan

Abstract

Colchicine, injected bilaterally into the forebrain of day-old chicks at times before and after one-trial avoidance learning, produced transient amnesia for one to three hours after learning, that could not be accounted for as a perceptual or attentional defect. The amnesia was dose dependent and was produced only when injections occurred within a limited period before and after learning. No amnesia occurred when injections were given 120 min before or 60 min later than the learning trial, nor at times prior to the retrieval test. During the amnesic period, new learning could occur and be retrieved 15 min later. The amnesia could be overcome by retention-testing or by a new, related, learning experience before or up to 30 min after onset of amnesia. Control birds injected with saline or lumicolchicine, a biologically inactive derivative of colchicine, showed normal retention. Vinblastine sulphate, which also interrupts microtubular networks and hence axonal flow, had no amnesic properties. Colchicine injections had no effect on the levels of acetylcholinesterase, choline acetyltransferase, glutamic acid decarboxylase, and muscarinic acetylcholine receptors in the whole forebrain or in forebrain synaptosomes during the amnesic p...Continue Reading

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Citations

Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·G Bensimon, R Chermat
Dec 3, 2005·Learning & Memory·Radmila MileusnicSteven P R Rose
Jan 12, 2010·Behavioural Brain Research·Nancy J Woolf, Larry L Butcher

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