Abstract
Mice were intraperitoneally infected with 2 × 10(8) cfu Staphylococcus aureus Xen 36 and treated with 2,130 AU (arbitrary units) nisin (equivalent to 27.7 μg pure nisin), a class Ia lantibiotic, over 7 days. The metabolic activity of S. aureus Xen 36, concluded from changes in cell bioluminescence, declined for the first 3.5 h, but increased over the next 24 h and remained at this level for the remainder of the 7-day trial. Similar results were obtained with heat-inactivated (25 min at 121 °C) nisin, suggesting that the decline in metabolic activity of S. aureus Xen 36 cannot be attributed to the bacteriostatic activity of nisin. The decline in lymphocyte numbers in infected mice was of smaller magnitude after treatment with active nisin compared to inactive nisin, suggesting that active nisin limited the apoptosis of lymphocytes. The drastic increase in neutrophil versus lymphocyte (N:L) ratio observed in the presence of active nisin suggested that the decline in metabolic activity of S. aureus Xen 36 was due to an immune response triggered by the infection. Nisin, active or inactive, stimulated the activity of cytokines interleukin-6, interleukin-10 and tumour necrosis factor. However, the overall immune response triggered by...Continue Reading
References
Aug 26, 1998·The New England Journal of Medicine·F D Lowy
Aug 14, 1999·Critical Care Medicine·R S HotchkissI E Karl
Jan 16, 2003·Fish & Shellfish Immunology·L VillamilB Novoa
Feb 18, 2005·Biotechnology Letters·Chan-Ick CheighYu-Ryang Pyun
Mar 15, 2006·Nature Reviews. Drug Discovery·Eefjan Breukink, Ben de Kruijff
Nov 28, 2007·Applied and Environmental Microbiology·M de KwaadstenietL M T Dicks
Nov 21, 2008·Letters in Applied Microbiology·M De KwaadstenietL M T Dicks
Mar 11, 2009·Antimicrobial Agents and Chemotherapy·Zhizeng SunLiandong Huan
Feb 24, 2010·Journal of Pharmacological and Toxicological Methods·R RinkG N Moll
Aug 10, 2010·Applied and Environmental Microbiology·Máire BegleyR Paul Ross
Oct 30, 2010·Letters in Applied Microbiology·A M BrandL M T Dicks
Nov 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Cornelis P C de JagerPeter C Wever
Jan 6, 2011·Expert Opinion on Biological Therapy·Julio Villatoro-HernandezOscar P Kuipers
Feb 5, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·D BegdeA Upadhyay
Jan 25, 2012·Journal of Applied Microbiology·A D van StadenL M T Dicks
Apr 23, 2013·FEMS Microbiology Letters·Jean Guy LeBlancLuis G Bermúdez-Humarán
Jun 1, 2010·Probiotics and Antimicrobial Proteins·M de KwaadstenietL M T Dicks
Citations
Jan 27, 2019·American Journal of Reproductive Immunology : AJRI·Zhifeng JiaBo Liu
Nov 20, 2019·Journal of Bacteriology·Julie N O'SullivanR Paul Ross
Jul 10, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Michelle V MouritzenHåvard Jenssen
Mar 28, 2019·Journal of Animal Physiology and Animal Nutrition·Joanna MałaczewskaAndrzej K Siwicki
Aug 9, 2019·Scientific Reports·Leané DreyerAnton D van Staden
Sep 26, 2020·Frontiers in Microbiology·Santosh Kumar TiwariMichael L Chikindas
Jan 7, 2021·Probiotics and Antimicrobial Proteins·Haodan ZhuKongwang He
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Silpa S, Rupachandra S
Dec 29, 2020·Peptides·Joanna Małaczewska, Edyta Kaczorek-Łukowska