PMID: 6408037Jun 1, 1983Paper

The effects of conventionally fractionated, extended portal radiotherapy on the human peripheral blood count

International Journal of Radiation Oncology, Biology, Physics
P N Plowman

Abstract

Conventionally fractionated, extended portal radiotherapy (CFEPRT) has been used to treat two diseases in which there was no marrow infiltration (viz. Hodgkin's disease and medulloblastoma). Blood count indices have been monitored during therapy and in the recovery phase. The lymphocytes were the most sensitive and the monocytes the most refractory leucocytes to change; the monocyte count tended to recover during CFEPRT. The platelet count fell gradually and soon after the neutrophil count. The nadir counts for white cells and platelets occurred early or toward the middle of CFEPRT, after which levels were maintained. The hemoglobin slightly and progressively declined. The patterns of change were similar for the two portals analyzed. Absolute eosinophilia occurred in 9 of the 53 CFEPRT patients, often in the recovery period. All patients who maintained their early nadir levels throughout the rest of the CFEPRT demonstrated fast recovery of all indices following completion of radiotherapy; the lymphocyte count recovered fastest. Recent prior CFEPRT or standard MVPP (nitrogen mustard, vinblastine, procarbazine, prednisolone) chemotherapy rendered the blood count more liable to radiation induced cytopenia. A lapse of more than 3 m...Continue Reading

References

May 13, 1978·British Medical Journal·A R TimothyA E Jones
Feb 1, 1979·International Journal of Radiation Oncology, Biology, Physics·R E Johnson
Jan 1, 1979·Nouvelle Revue Française D'hématologie·L G Lajtha
Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·J SlaninaR Stiasny
Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·M RotmanS Stowe
Apr 1, 1975·British Journal of Haematology·L G Lajtha
Jan 1, 1973·Oncology·F M MuggiaH Wohl
Mar 1, 1972·Cell and Tissue Kinetics·J Gidali, L G Lajtha
Jun 1, 1974·British Journal of Haematology·R H Begent, E Wiltshaw
May 1, 1974·British Journal of Haematology·M A MooreD G Penington
Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·C W Gurney, W Fried
Apr 1, 1970·Annals of Internal Medicine·R E Curran, R E Johnson
Jan 1, 1980·Acta Haematologica·H DalyI J Temperley
Aug 29, 1981·British Medical Journal·D A RobertsonM S Losowsky
Jan 1, 1981·International Journal of Radiation Oncology, Biology, Physics·S StroberH S Kaplan

❮ Previous
Next ❯

Citations

May 31, 2001·International Journal of Radiation Oncology, Biology, Physics·B ZachariahA B Zachariah
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·K R BlankG D Kao
Aug 2, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P MatthiessenG Arbman
Dec 24, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L ZorcoloG Casula
Oct 2, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S JefferiesM Brada
Jul 6, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·F Drouet, J-L Lagrange
Apr 1, 1985·International Journal of Radiation Oncology, Biology, Physics·M H MaorJ van Eys
Sep 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tone FokstuenBengt Glimelius
Jan 27, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L B JohnsonB Jeppsson
Mar 14, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A HartleyJ I Geh
May 7, 2014·Biochimica Et Biophysica Acta·Daniel HeylmannBernd Kaina
Aug 1, 1993·The British Journal of Radiology·W KrueckM Bamberg
Jul 1, 1995·Medical and Pediatric Oncology·L B MarksH S Friedman
Jan 1, 1992·Medical and Pediatric Oncology·L B MarksB M Hockenberger
Jan 30, 2021·Scientific Reports·Daniel HeylmannBernd Kaina
Nov 24, 2020·Physics in Medicine and Biology·Harald PaganettiAntony John Lomax
Mar 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Adam R WolfeTerence M Williams
Jul 16, 2021·International Journal of Radiation Biology·Calvin N LeungRoger W Howell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.