The effects of cyclosporin A and cyclophosphamide on the populations of B and T cells and virus in the Harderian gland of chickens vaccinated with the Hitchner B1 strain of Newcastle disease virus

Veterinary Immunology and Immunopathology
P H RussellT F Davison

Abstract

The cellular response to conjunctival vaccination with the Hitchner B1 strain of Newcastle disease virus was studied in the Harderian gland (HG) by immunohistochemistry. Bu-1+ cells and all subpopulations of T cells, (CD3+, CD4+, CD8+, TCR gamma delta, TCR alpha beta 1, and TCR alpha beta 2) were in the interstitial tissue between the ducts and the acini. Plasma cells with cytoplasmic IgM were more dispersed than the other cells and outlined the acini. Bu-1+ cells and all subpopulations of T cells increased at least three-fold after vaccination when compared to uninfected birds on the basis of the average cell counts in sections taken at 3, 5, 7, 10, 14, and 20 days after vaccination. The most marked increase was in the CD8+ cells which increased six-fold. Virus replicated for 10 days in cyclophosphamide (Cy) treated birds and for 7 days in cyclosporin A (CsA) treated birds compared with 5 days in untreated birds. Cy treatment prevented an antibody response to NDV and reduced Bu-1+ and IgM cells in the HG by 20-fold. Cy treatment resulted in a doubling of the number of T cells in the HG but these T cells may have been transiently disabled because it also caused a poor response of the lymphocytes in whole blood to the T cell mit...Continue Reading

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Citations

Mar 16, 2000·Developmental and Comparative Immunology·B S SealH S Sellers
Dec 29, 2000·Comparative Immunology, Microbiology and Infectious Diseases·A PanshinM Lipkind
Apr 3, 2007·Journal of the American Veterinary Medical Association·Matthew S JohnstonKaren L Rosenthal
Jun 27, 2008·Developmental and Comparative Immunology·M P AriaansL Vervelde
Nov 16, 2007·International Journal of Immunogenetics·K A AhmedT J Rasool
Apr 30, 2013·Developmental and Comparative Immunology·Darrell R KapczynskiPatti J Miller
Apr 16, 2003·Journal of Medical Entomology·William K ReisenThomas Laver
Oct 5, 2007·Expert Review of Anti-infective Therapy·Richard K Beal, Adrian L Smith
Jul 31, 2004·Avian Diseases·M J Pantin-JackwoodG R Huff

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