PMID: 591196Jan 1, 1977

The effects of d-amphetamine and temperature on p-cresol and pentylenetetrazol induced convulsions

The International Journal of Neuroscience
S Yehuda, R L Carasso


Each of twelve (12) rats were subjected to temperatures of 37c, 20c, and 4c in an environmental chamber. Seizure responses to p-cresol injections produced a U-shaped function, with minimal seizures occuring at 20c. Subsequent administration of d-amphetamine eliminated seizures, except at 4c, at which temperature only stereotyped behavior was observed. Environmental temperature effects on metrazol injections in a second group (N=72) seemed to increase linearly with respect to seizure susceptibility and mortality, although latency to first seizure was also a U-shaped function. The findings are discussed in the context of developing a model of epilepsy appropriate for behavioral research.


Jan 1, 1968·Annual Review of Pharmacology·I J Kopin


Mar 11, 1994·European Journal of Pharmacology·S YehudaD I Mostofsky
Dec 11, 2007·Epilepsy & Behavior : E&B·Alcy R TorresJoseph Gonzalez-Heydrich
Jan 11, 2000·Seizure : the Journal of the British Epilepsy Association·P E Smith, A McBride

Related Concepts

Dose-Response Relationship, Drug
Reaction Time
Non-epileptic Convulsion

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