The effects of daily stress and stressful life events on the clinical symptomatology of patients with lupus erythematosus

Psychosomatic Medicine
M I Peralta-RamírezGroup Lupus Virgen de las Nieves

Abstract

The purpose of this study was to verify whether stress worsens the clinical symptomatology perceived by patients with lupus erythematosus. Toward this end, we considered two types of stressors-daily stress and high-intensity stressful life events. In 46 patients with systemic lupus erythematosus and 12 patients with chronic lupus discoid, we studied the stress they experienced daily for 6 months and their disease symptoms. During this period, we also analyzed the levels of C3 and C4 complements and anti-DNAn antibodies. The systemic lupus erythematosus activity (assessed by the Systemic Lupus Activity Measures) and cumulative organ damage (assessed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index) were also analyzed. We did not find that high-intensity stressful life events produced a worsening of the symptomatology of the disease. However, using a time-series analysis (Box-Jenkins), we found that a high percentage of lupus patients (74.1%) perceived a worsening in their clinical symptomatology due to the effects of daily stress. Of this 74.1%, 53.4% worsened the same day they suffered the perceived daily stress, and the remaining 20.7% experienced an increase in symptoms b...Continue Reading

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Citations

Mar 19, 2008·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Carolyn Y FangSteven D Douglas
Jun 20, 2007·International Journal of Clinical Practice·J F Simard, K H Costenbader
Aug 26, 2006·Annual Review of Psychology·Annette L StantonHoward Tennen
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Feb 2, 2013·Arthritis Care & Research·Nuria Navarrete-NavarreteMaria Isabel Peralta-Ramirez
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May 23, 2014·Psychosomatic Medicine·Carolyn Y FangMarilyn Tseng
Jan 11, 2007·Lupus·M I Peralta-RamírezM Pérez-García
Aug 31, 2017·Stress : the International Journal on the Biology of Stress·Eva Montero-LópezMaría Isabel Peralta-Ramírez
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Feb 27, 2021·Medicina clínica·Ana Santos-RuizMaría Isabel Peralta-Ramírez
Mar 24, 2021·Medicina Clínica·Ana Santos-RuizMaría Isabel Peralta-Ramírez

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