The effects of deep-brain non-stimulation in severe obsessive-compulsive disorder: an individual patient data meta-analysis

Translational Psychiatry
Koen SchruersWolfgang Viechtbauer

Abstract

Non-intervention-related effects have long been recognized in an array of medical interventions, to which surgical procedures like deep-brain stimulation are no exception. While the existence of placebo and micro-lesion effects has been convincingly demonstrated in DBS for major depression and Parkinson's disease, systematic investigations for obsessive-compulsive disorder (OCD) are currently lacking. We therefore undertook an individual patient data meta-analysis with the aim of quantifying the effect of DBS for severe, treatment-resistant OCD that is not due to the electrical stimulation of brain tissue. The MEDLINE/PubMed database was searched for double-blind, sham-controlled randomized clinical trials published in English between 1998 and 2018. Individual patient data was obtained from the original authors and combined in a meta-analysis. We assessed differences from baseline in obsessive-compulsive symptoms following sham treatment, as measured by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Four studies met the inclusion criteria, randomizing 49 patients to two periods of active or sham stimulation. To preclude confounding by period effects, our estimate was based only on data from those patients who underwent sha...Continue Reading

References

Oct 1, 1990·Psychiatry Research·S W KimM Kuskowski
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Aug 11, 2001·Science·R de la Fuente-FernándezA J Stoessl
Sep 29, 2001·The New England Journal of Medicine·UNKNOWN Deep-Brain Stimulation for Parkinson's Disease Study GroupA E Lang
Mar 24, 2004·Parkinsonism & Related Disorders·Raúl de la Fuente-Fernández
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron C McIntyreJerrold L Vitek
Jun 26, 2004·The Journal of Physiology·Trent AndersonZelma H T Kiss
Mar 2, 2005·Biological Psychiatry·James L AbelsonBruno Giordani
Mar 3, 2005·Acta Psychiatrica Scandinavica·K SchruersE Griez
May 28, 2005·Psychological Medicine·Arif KhanWalter A Browns
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabrizio BenedettiJon-Kar Zubieta
May 25, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Rodrigo MercadoChristopher R Honey
Jan 30, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzSue Leurgans
Nov 14, 2008·The New England Journal of Medicine·Luc MalletUNKNOWN STOC Study Group
Feb 25, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·J M MannM S Okun
Dec 16, 2009·Neurosurgery·Shokei YamadaDaniel J Won
Feb 4, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Angelo FranziniGiovanni Broggi
Aug 4, 2010·Archives of General Psychiatry·Sarah C LidstoneA Jon Stoessl
Oct 6, 2010·Archives of General Psychiatry·Damiaan DenysRick Schuurman
Nov 17, 2012·Stereotactic and Functional Neurosurgery·Tomasz TykockiTomasz Mandat
Jul 16, 2013·Annals of Neurology·Simon LittlePeter Brown
Dec 18, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marilena AielloRaffaella I Rumiati
Nov 18, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·W M Michael SchüpbachGünther Deuschl
Mar 10, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Tiago A MestreMichael S Okun
Sep 14, 2016·Behavior Research Methods·Steven G Luke
Sep 30, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hemmings WuBart Nuttin
Nov 14, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A E P MuldersY Temel
May 20, 2017·International Review of Psychiatry·Ilse GraatDamiaan Denys
Aug 13, 2017·Journal of Neuroengineering and Rehabilitation·Mahboubeh Parastarfeizabadi, Abbas Z Kouzani

❮ Previous
Next ❯

Software Mentioned

lmerTest
lme4
R

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.