Abstract
Diabetes has long been known to have an impact on bone repair. More recently, however, most diabetic patients receive medications to normalise this hyperglycaemic environment. To date, no studies have investigated the effects of diabetic medications on fracture healing in humans. Patients were identified from two tertiary trauma centres. Inclusion criteria were adult patients having sustained a closed diaphyseal femoral or tibial fracture, treated surgically. Exclusion criteria were open, pathological or peri-prosthetic fractures, and patients having sustained polytrauma. Matched non-diabetic controls were identified, matched for age, sex, fracture classification and osteosynthesis. Output measures were: time to callus first appearance, bridging of involved cortices and time to union, along with the eventual outcome: union/non-union. A total of 36 (25 males) eligible patients were identified with a control group of 166 patients (138 males). ANOVA demonstrated class of medication to have a significant effect at two of the three time points and on the eventual outcome. Multiple regression analysis also demonstrated significant impact (p = 0.02). All classes of medication demonstrated anti-osteogenic effects compared to the contro...Continue Reading
References
Sep 1, 1991·Calcified Tissue International·R Bouillon
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Heather A BeamSheldon S Lin
May 27, 2003·Diabetes·Ronaldo B SantanaPhilip C Trackman
Sep 10, 2004·Calcified Tissue International·N FollakH Merk
Sep 9, 2005·Medical Hypotheses·S YamagishiH Inoue
Mar 28, 2006·European Journal of Pharmacology·Ana M CortizoLeón Schurman
Jun 14, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SaitoK Marumo
Feb 1, 2007·The Journal of Clinical Endocrinology and Metabolism·Andrew GreyIan R Reid
Aug 3, 2007·Bone·Tzu-Hung LinWen-Mei Fu
Aug 30, 2008·Biochemical and Biophysical Research Communications·Ippei KanazawaToshitsugu Sugimoto
Nov 18, 2008·Bone·Rayyan A KayalDana T Graves
Dec 31, 2008·Journal of Cellular Biochemistry·Keith R ShockleyBeata Lecka-Czernik
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Silvina MolinuevoClaudia Sedlinsky
Mar 24, 2010·European Journal of Pharmacology·Ying GaoJing Hu
Sep 3, 2010·Current Osteoporosis Reports·Beata Lecka-Czernik
Dec 24, 2010·Endocrinology·Kimberly A KyleMarc D Grynpas
Dec 8, 2011·Expert Opinion on Drug Safety·Christopher M SimpsonPeter V Giannoudis
Citations
May 23, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lucian B SolomonGerald J Atkins
Aug 19, 2016·Expert Opinion on Drug Delivery·A H de BoerH W Frijlink
Feb 9, 2018·Frontiers in Endocrinology·Carlos MarinKatleen Vandamme
Jul 4, 2020·Molecular Medicine·Aleksandra Skubis-SikoraJoanna Gola