The effects of diet and sex in amyotrophic lateral sclerosis

Revue neurologique
J A Pape, J H Grose

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no known cure. Approximately 90% of ALS cases are sporadic, suggesting there are multiple contributing factors that influence the disease risk, onset, and progression. Diet and sex are two factors that have been reported to alter ALS risk, onset and progression in humans and in animal models, providing potential modifiers of disease. Several epidemiological studies have identified diets that positively affect ALS patients, including various high-calorie fat or sugar-based diets, while animal models have been developed to test how these diets are working on a molecular level. These diets may offset the metabolic alterations that occur in ALS, such as hypermetabolism, lowered body mass index(BMI), and hyperlipidemia. Sex-dependent differences have also come forth from large-scale epidemiological studies as well as mouse-model studies. In addition, sex hormones have been shown to affect disease risk or progression. Herein, studies on the effects of diet and sex on ALS risk, onset, and progression will be reviewed. Understanding these diet- and sex-dependent outcomes may lead to optimized patient-specific therapies for ALS.

Citations

May 28, 2020·International Journal of Molecular Sciences·Francesca TrojsiGioacchino Tedeschi
Jan 28, 2021·Brain Sciences·Hasan Aykut KarabogaResit Celik
Jan 11, 2021·Journal of the Neurological Sciences·Mariana PereiraMamede de Carvalho
Apr 4, 2021·International Journal of Molecular Sciences·Elisabeth TraiffortAmina Zahaf
May 2, 2021·Communications Biology·Michael Sloth TrabjergJohn Dirk Vestergaard Nieland
Jul 3, 2021·Biomolecules·Laura FerriLaura Bonanni
Jul 3, 2021·International Journal of Molecular Sciences·Elena ObradorJosé M Estrela
Sep 2, 2021·Endocrinology·Nathalie SumienRebecca L Cunningham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
B R Brooks
Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Kay A LawtonJames D Berry
Current Opinion in Neurology
David Brenner, Jochen H Weishaupt
The Journal of Clinical Investigation
Owen M PetersRobert H Brown
© 2021 Meta ULC. All rights reserved