The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, disease and toxicology

The Journal of Nutrition
K P KeenanJohn B Coleman

Abstract

Overfeeding by ad libitum (AL) food consumption is the most significant, uncontrolled variable affecting the outcome of the current rodent bioassay. The correlation of food consumption, the resultant adult body weight and the 2-y survival in Sprague-Dawley rats is highly significant. Feeding natural ingredient diets that varied in protein, fiber and metabolizable energy content did not improve low 2-y survival if Sprague-Dawley rats were allowed AL food consumption. Moderate dietary restriction (DR) of all diets tested significantly improved survival and delayed the onset of spontaneous degenerative disease (i.e., nephropathy and cardiomyopathy) and diet-related tumors. By 2 y, moderate DR resulted in an incidence of spontaneous tumors similar to that seen with AL consumption; however, the tumors were more likely to be incidental and did not result in early mortality. There was a decreased age-adjusted incidence in pituitary and mammary gland tumors, but tumor volume and growth time were similar in the AL and DR groups, indicating a similar tumor progression with a delay in tumor onset. Moderate DR did not significantly alter drug-metabolizing enzyme activities or the toxicologic response to five pharmaceuticals tested at maxim...Continue Reading

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Citations

Feb 4, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Edward J Masoro
Sep 9, 2006·The Journal of Toxicological Sciences·Tomoyuki MoriyamaMasaru Nishikibe
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Edward J Masoro
Sep 28, 2014·International Journal of Toxicology·Madhav G ParanjpeReem H Elbekai
Dec 7, 2002·Nutrition and Cancer·Cristina Rodríguez-BurfordClinton J Grubbs
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Victoria AyalaReinald Pamplona
Sep 3, 2011·Journal of Applied Toxicology : JAT·Adam Hargreaves, Johannes Harleman
Aug 6, 2013·Integrated Environmental Assessment and Management·David B MayfieldAnne Fairbrother
Jul 3, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K P KeenanR Dixit
Aug 26, 2009·Journal of Gastroenterology and Hepatology·Umbreen AhmedPhillip S Oates
Apr 13, 2017·Laboratory animal research·Hye-Jun ShinMyeon-Woo Chung
Jun 4, 2008·Cancer Research·Valeri V MossineThomas P Mawhinney
May 4, 2021·Frontiers in Veterinary Science·Cristina PereaCruz Miguel Cendán
Dec 3, 2003·Toxicology and Applied Pharmacology·Julian E A LeakeyWilliam T Allaben
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
May 31, 2012·Chemical Research in Toxicology·Gale B Carey, Lisa C Merrill

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