The effects of dietary flaxseed on the Fischer 344 rat: II. Liver gamma-glutamyltranspeptidase activity

Cell Biochemistry and Function
Susan J HemmingsDominika Czechowicz

Abstract

The effect of 10% flax chow consumption from the 30th to the 130th day after birth was examined in male Fischer 344 rats. The effects of both the high lignan/high oil Norlin strain and a high lignan/low oil Solin strain of flaxseed were compared. Physically and behaviourally there were no differences in rats belonging to the three dietary groups at any time. At 50 and 100 days of dietary exposure, blood glucose levels were the same in Norlin and Solin flax chow-fed and as well as regular chow-fed rats; there were no signs of toxicity in the Norlin and Solin flax-fed rats since their plasma levels of alanine aminotransferase were the same and equal to those of regular chow-fed rats. The activity of gamma-glutamyltranspeptidase (gammaGT) displayed an increase in the liver homogenates of flax chow-fed rats. This increase was the same in Norlin and Solin flax-fed rats at 50 and 100 days. Thus the liver effect was not oil, but lignan, likely secoisolariciresinol diglucoside (SDG), induced and was effected early on, and sustained, after flax exposure. The degree of heat activation of liver homogenate gammaGT was the same in regular chow-fed and flax chow-fed rats. Compared to liver homogenate gammaGT activity, the soluble form of gam...Continue Reading

Citations

Sep 9, 2005·Cell Biochemistry and Function·Susan J Hemmings, Xiuyuan Song
Feb 27, 2015·The British Journal of Nutrition·Jatinder Kaur MukkerJane Alcorn
Feb 8, 2007·Organic & Biomolecular Chemistry·Farah S HosseinianEd S Krol
Jul 23, 2019·Phytotherapy Research : PTR·Adchara PrommabanSomdet Srichairatanakool

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