PMID: 124148Mar 1, 1975

The effects of diethyl ether, enflurane, and isoflurane at the neuromuscular junction

B E Waud, D R Waud


The actions of diethyl ether, enflurane, and isoflurane at the neuromuscular junction were examined in isolated guinea pig lumbrical muscles. These anesthetics depressed the ability of carbachol to depolarize the endplate region; this depression of depolarization did not show competitive kinetics. None of the anesthetics altered the affinity of the acetylcholine receptor for d-tubocurarine, i.e., the dissociation constant of d-tubocurarine was unchanged. Since diethyl ether, enflurane, and isoflurane produced no observable alteration of the receptor, the antagonism of the drug-induced depolarization of the neuromuscular junction appears to be exerted at a stage subsequent to reaction with the receptor. (Key words: Anesthetics, volatile, diethyl ethers; Anesthetics, volatile, euflurane; Anesthetics, volatile, isoflurane; Neuromuscular relaxants, d-tubocurarine; Neuromuscular junction.).


May 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J E ReidA H Hayes
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A P YoungD S Sigman
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J Lechleiter, R Gruener
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·T Heier, P A Steen
Mar 1, 1992·Electroencephalography and Clinical Neurophysiology·J L StoneP Roccaforte
Nov 21, 1984·Journal of Theoretical Biology·M Stone
Aug 1, 1986·Acta Anaesthesiologica Scandinavica·L Lindgren, L Saarnivaara
Jun 29, 2002·Anesthesia and Analgesia·Hironori ItohShunichi Nitta
Mar 7, 2000·Anesthesia and Analgesia·T J ZhouT Webb

Related Concepts

Acetylcholine Sulfate (1: 1)
Chromatography, Gas-Liquid
Neuromuscular Nondepolarizing Agents
Dose-Response Relationship, Drug
Drug Interactions
Ethyl Ethers
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