The effects of different amounts of drug microspheres on the vivo and vitro performance of the PLGA/β-TCP scaffold

Designed Monomers and Polymers
Liulan LinNiandong Qian

Abstract

OIC-A006 (BMPs osteogenesis compounds), can stimulate bone marrow mesenchymal stem cells ALP, OPN, OC, Cbfal expression. To stimulate new bone formation in the body. We postulate different amounts of drug microspheres on the PLGA/β-CPT scaffold can produce the effects on performance and sustained release characteristics. In this paper, through adding different amount of carrier drug microsphere, three concentrations scaffolds which are 12.5, 18.75 and 25 μmol/L are prepared by adding different amounts of drug-loaded microspheres. Hereafter called OICM/CPT-200, OICM/CPT-300, OICM/CPT-400. We implant them in rat femur diameter 3 mm depth of 3 mm hole for eight weeks. The degradation, microsphere, delivery properties, with X-ray, micro-CT and histology are tested. Results show that the contain carrier drug microsphere scaffolds become radiopaque, and the gaps between the scaffold and radial cut ends are often invisible. This preliminary study reveals that different carrier drug microsphere has a corresponding effect the performance of stent body, OICM/CPT - 200 scaffolds induction effect is best. Illustrates that the low concentration load OIC-A006 microspheres can promote bone healing, and high concentration of OIC-A006 micro bal...Continue Reading

References

Sep 4, 2012·Trends in Biotechnology·Susmita BoseAmit Bandyopadhyay
Dec 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huanan WangSander C G Leeuwenburgh
Mar 23, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Liulan LinMinglun Fang
Apr 17, 2013·International Immunopharmacology·Yan BaiXiming Pu
Aug 27, 2013·Acta Biomaterialia·Anwarul HasanAli Khademhosseini
Oct 24, 2013·Biomedical Microdevices·Tina Qing HuangShaochen Chen
Nov 5, 2013·Acta Biomaterialia·S M GiannitelliA Rainer
Jan 15, 2014·Acta Biomaterialia·Tanya J LevingstoneJohn P Gleeson
Mar 5, 2014·International Journal of Molecular Sciences·Piergiorgio GentilePaul V Hatton
May 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akhilesh K GaharwarAli Khademhosseini
May 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pyung-Hwan KimJe-Yoel Cho
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Xue ZhangXu-Dong Sun
Oct 16, 2014·International Journal of Biological Macromolecules·K T ShalumonK P Chennazhi
Dec 3, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Justyna SkowyraMohamed A Alhnan
Jul 3, 2015·Acta Biomaterialia·S M GiannitelliA Rainer
Sep 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shushi KabuVinod Labhasetwar
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sudipta SenapatiPralay Maiti

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
light microscopy
electron microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Dong-Feng ChenMin Xu
Zhonghua wai ke za zhi [Chinese journal of surgery]
L Wang, G Dang
Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Mengchun QiLichi Han
© 2022 Meta ULC. All rights reserved