The effects of different anaesthetic treatments on the adreno-cortical functions and glucose levels in NZW rabbits

Journal of Physiology and Biochemistry
J C IlleraM Illera

Abstract

The effects of five anaesthetics on the corticosterone, cortisol and glucose concentrations were investigated in the NZW rabbit. Sixty animals were assigned to 6 treatment groups (n= 10 per group): control ( iv saline solution injection), ketamine (10 mg/kg iv) with either xylazine (3 mg/kg iv) or diazepam (2 mg/kg iv), pentobarbitone (30 mg/kg iv), thiopentone (20 mg/kg iv) and fentanyl/droperidol (1 mg/kg sc). Plasma glucocorticoids were measured by competitive enzymeimmunoassay EIA and glucose by an autoanalyzer, previously validated for this species in both cases. Blood samples were obtained at 6 time-points: before injection, at 10, 30, 60, 120 min and 24 h after injection of the anaesthetics/saline. A significant decrease of plasma glucocorticoids at 10-60 min was observed in the pentobarbitone and fentanyl/ droperidol groups, whereas the administration of ketamine/diazepam or thiopentone stimulated plasma glucocorticoid release, principally in the recovery period. However, in the ketamine/xylazine group no changes were observed in the glucocorticoid levels, except for a significative increase of cortisol at 60-120 min. Glucose levels significantly increased after ketamine/diazepam administration and principally, after ke...Continue Reading

References

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Citations

Nov 27, 2008·Archives of Orthopaedic and Trauma Surgery·Tang HuiDing Jing
Jan 20, 2012·Journal of the American Veterinary Medical Association·Brice S ReynoldsCatherine Trumel
Jun 30, 2007·Journal of Endocrinological Investigation·J A Llompart-PouJ Ibáñez
Nov 14, 2008·Chronobiology International·Garance DispersynYvan Touitou
Dec 4, 2014·International Journal of Cardiology·Flavia FranconiIlaria Campesi
Jan 2, 2008·The Veterinary Journal·M Carmen MarcaM Jesús Rodríguez-Yoldi
May 13, 2014·Journal of Medical Primatology·Jong Min KimChung-Gyu Park
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Rachel A BaarElizabeth J Parks
Sep 20, 2018·PloS One·Katharina HohlbaumChrista Thöne-Reineke
Mar 8, 2019·Journal of Cellular Physiology·Reza Alizadeh, Ziba A Fard
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·J Boudreau, L Hoffman-Goetz
Mar 19, 2015·American Journal of Therapeutics·Ebtsam A MohammadAmr A Abd-Elghany
Oct 16, 2004·The Journal of Antimicrobial Chemotherapy·Ashraf A KadryMohsen A Bayomi

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