The effects of dihydroartemisinin on inflammatory bowel disease-related bone loss in a rat model.

Experimental Biology and Medicine
Xingtao GeYu Yang

Abstract

Bone loss is one of the important extra-intestinal manifestations in patients with inflammatory bowel diseases (IBDs). Compounds derived from natural products have been used to treat IBDs. However, the role of natural products on IBD-induced bone loss is not completely clarified. In the present study, we observed the effects of dihydroartemisinin (DHA), an antimalaria drug, on IBD and IBD-induced bone loss in a rat model. Chronic IBD model was established in Sprague-Dawley rats by giving them 2.5% dextran sodium sulfate in drinking water. DHA was given by intraperitoneal injection. Blood, colon, and bone samples were collected for biomarker assay and histological analysis. There was an obvious increase in tumor necrotic factor (TNF) α and receptor activator of nuclear factor (NF)-kB ligand (RANKL), and decrease in procollagen type 1 N-terminal propeptide (P1NP) level in IBD groups compared with the normal control (p < 0.05). The disease activity score of IBD rats was significantly higher than the control (p < 0.01). Obvious decrease in disease activity score, TNFα, and RANKL level and increase in P1NP were observed in DHA-treated IBD rats. Bone loss, shown as the decrease in bone mineral density, bone volume fraction, and trabe...Continue Reading

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Citations

Sep 29, 2018·International Journal of Molecular Sciences·Miki MatsuiSusumu Ohya
Jun 21, 2021·Medicinal Research Reviews·Yuqing MengJigang Wang
Jul 22, 2021·Medicinal Research Reviews·Thomas Efferth, Franz Oesch

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Methods Mentioned

BETA
X-ray
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
SPSS16

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