The effects of dopamine receptor agonists and antagonists on the secretory rate of cockroach (Periplaneta americana) salivary glands

Journal of Insect Physiology
Susanna MargW Blenau

Abstract

The acinar salivary glands of the cockroach, Periplaneta americana, are innervated by dopaminergic and serotonergic nerve fibers. Serotonin stimulates the secretion of protein-rich saliva, whereas dopamine causes the production of protein-free saliva. This suggests that dopamine acts selectively on ion-transporting peripheral cells within the acini and the duct cells, and that serotonin acts on the protein-producing central cells of the acini. We have investigated the pharmacology of the dopamine-induced secretory activity of the salivary gland of Periplaneta americana by testing several dopamine receptor agonists and antagonists. The effects of dopamine can be mimicked by the non-selective dopamine receptor agonist 6,7-ADTN and, less effectively, by the vertebrate D1 receptor-selective agonist chloro-APB. The vertebrate D1 receptor-selective agonist SKF 38393 and vertebrate D2 receptor-selective agonist R(-)-TNPA were ineffective. R(+)-Lisuride induces a secretory response with a slower onset and a lower maximal response compared with dopamine-induced secretion. However, lisuride-stimulated glands continue secreting saliva, even after lisuride-washout. Dopamine-induced secretions can be blocked by the vertebrate dopamine recep...Continue Reading

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Citations

Mar 30, 2013·Invertebrate Neuroscience : in·Takayuki WatanabeHitoshi Aonuma
Jan 9, 2014·International Journal of Molecular Sciences·Britta TroppmannWolfgang Blenau
Aug 19, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Radomír SochaRostislav Zemek
May 4, 2007·Journal of Insect Physiology·Britta TroppmannWolfgang Blenau
Jun 30, 2005·Archives of Insect Biochemistry and Physiology·Wolfgang Blenau
Jun 30, 2005·Archives of Insect Biochemistry and Physiology·Wolfgang Blenau, Arnd Baumann
Jun 20, 2006·Archives of Insect Biochemistry and Physiology·Bernd WalzWolfgang Blenau
Sep 10, 2014·Parkinsonism & Related Disorders·Prachaya SrivanitchapoomMark Hallett
Apr 16, 2015·Frontiers in Behavioral Neuroscience·Xiaojiao GuoLe Kang
Oct 31, 2017·International Journal of Molecular Sciences·Wolfgang BlenauArnd Baumann
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Jan 19, 2021·Journal of Insect Physiology·Alexander Soohoo-HuiDaniel R Swale
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Jun 10, 2009·Insect Biochemistry and Molecular Biology·Hiroto OhtaKiyoshi Asaoka

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