PMID: 9631954Jun 19, 1998Paper

The effects of dopaminergic agents on reaction time in rhesus monkeys

Psychopharmacology
Michael R Weed, L H Gold

Abstract

Many CNS pathologies, including Parkinson's, Alzheimer's and Huntington's diseases, as well as AIDS dementia complex, involve some degree of movement dysfunction. Reaction time (RT) performance has been shown to be a sensitive measure of motor function for these disorders. Useful models of RT performance exist in a variety of species, but few are performed in the same manner as with humans. To facilitate species comparisons, the present RT task was developed from a human RT task. Dopaminergic drugs were then used to characterize the sensitivity of the model to CNS changes and to investigate their effects on RT performance in intact rhesus monkeys. With cumulative dosing, the selective dopamine receptor antagonists (D1) SCH 39166 and (D2) raclopride produced dose-dependent slowing of RT performance. Results following bolus administration of these drugs were consistent with the cumulative dosing procedure, although of smaller magnitude and higher variability. Amphetamine had no significant effect on group RT performance with either dosing scheme, but RT performance in individual monkeys was either speeded or slowed by d-amphetamine. The present results suggest that blockade of either D1-like or D2-like dopamine receptors can slow...Continue Reading

Citations

Apr 28, 2004·Psychopharmacology·Simon N KatnerMichael A Taffe
Mar 17, 2004·Brain Research. Cognitive Brain Research·Simona SpinelliChristopher R Pryce
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Robert D HienzJoseph V Brady
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Michael A TaffeLisa H Gold
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Sep 18, 2002·Drug and Alcohol Dependence·Michael A TaffeLisa H Gold
Nov 11, 1999·Brain Research. Cognitive Brain Research·M A TaffeL H Gold
Dec 8, 2009·The Journal of Pharmacology and Experimental Therapeutics·Donna M PlattRoger D Spealman
Sep 4, 2008·Radiation Research·Robert D HienzMichael R Weed
Jan 31, 2016·The Journal of Pharmacology and Experimental Therapeutics·Brian D KangasJack Bergman
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Jonas FizetHélène Meunier
Aug 19, 2005·Schizophrenia Bulletin·Trevor W Robbins
Dec 14, 2016·The Quarterly Journal of Experimental Psychology : QJEP·Ruth S OgdenCatharine Montgomery
Jul 9, 2002·Cephalalgia : an International Journal of Headache·J van der PostJ M A van Gerven
Oct 8, 1999·Acta Neurologica Scandinavica·T MüllerH Przuntek
Mar 14, 2021·The Journal of Pharmacology and Experimental Therapeutics·Chad R JohnsonJames H Woods

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