The effects of doxorubicin on ventricular tachycardia

Circulation
H le MarecM R Rosen

Abstract

Doxorubicin, in concentrations that have no effect on fast or slow response action potentials, has been shown to suppress ouabain-induced delayed afterdepolarizations. In this study, we used standard microelectrode techniques to determine the effects of doxorubicin on isolated canine Purkinje fibers. We studied automaticity induced at normal and low membrane potentials, conduction in normal and K+-depolarized Purkinje fibers, and triggered activity induced by ouabain and by experimental myocardial infarction. Doxorubicin, 50 microM, suppressed the triggered activity and the delayed afterdepolarizations that induced it, but had no effect on the other variables. We then studied the effects of intravenous doxorubicin, 16 to 64 mg/m2 body surface area, on ouabain-induced ventricular tachycardia and the ventricular tachycardia that occurs 24 hr after ligation of the left anterior descending coronary artery in the intact dog. There was no effect on the infarct-induced arrhythmia, but concentrations of doxorubicin that had no other effect on the electrocardiogram suppressed those ouabain-induced arrhythmias that appeared to have been triggered. The automatic arrhythmias induced by ouabain were not affected. Both the latter mechanisms ...Continue Reading

References

May 1, 1977·Progress in Cardiovascular Diseases·G R Ferrier
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Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
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Apr 1, 1981·The American Journal of Physiology·M R RosenR M Weiss

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Citations

Oct 14, 2010·Biological Trace Element Research·Nurcan DursunFigen Oztürk
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robin A FelderPedro A Jose
May 28, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi AshiharaMakoto Ito
Oct 12, 1999·Journal of Cardiovascular Electrophysiology·M Boutjdir

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