PMID: 15222272Jun 30, 2004Paper

The effects of DPPH on cochlear microcirculation

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Min Chen, Weijia Kong

Abstract

To investigate the effects of free radical, 1, 1-Diphenyl-2-picylhydrazyl(DPPH), on cochlear blood flow. Twenty guinea pigs were divided into 3 groups at random, 6 for control group, 6 for 1 mmol/L of DPPH group and 8 for 0.1 mmol/L of DPPH group. 2 microliters vehicle or drugs were dropped into round window membrane. Cochlear microcirculation was monitored by laser Doppler flowmeter and the mean arterial blood flow(MABP), which transferred by pressure conductor sensor and preamplifier, was simutaneously recorded by a computer. MABP was stable throught the experiment. Cochlear blood flow increased 12.49% (P < 0.05) in 1 mmol/L group, and decreased 3.02% (P < 0.05). In control group cochlear microcirculation had no significant changes. DPPH has effects on cochlear microcirculation. The mechanism still need to be explored later.

References

Jan 1, 1989·Acta Oto-laryngologica. Supplementum·S K JuhnM Goycoolea
Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H YamaneA Kojima

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Citations

Sep 12, 2012·International Journal of Biomedical Imaging·Ajna Borogovac, Iris Asllani
Mar 17, 2007·Population Studies·Siu Lan Karen Cheung, Jean-Marie Robine

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