The effects of drugs on pacemaker regions of isolated rabbit renal pelvis

European Journal of Pharmacology
M del TaccaC Bernardini


Acetylcholine failed to change the frequency of spontaneous contractions in the proximal region of isolated rabbit renal pelvis, but significantly increased the contractile frequency in the middle and distal regions, which then reached similar levels to those of the proximal region. Pretreatment with reserpine caused a decrease in the frequency of spontaneous contractions in the proximal, but not in the middle or distal regions. Reserpine-pretreated tissues developed hypersensitivity to catecholamines, while acetylcholine produced effects similar to those observed in control preparations. Atropine and N-methyl-scopolamine antagonized the action of acetylcholine in both the middle and the distal regions, suggesting that the action was exerted through muscarinic receptors. Adrenaline and alpha-stimulating drugs, but not isoprenaline, significantly increased the contractile frequency of all three tissues: the increase in the proximal region reached levels in excess of its fundamental maximal frequency. Phentolamine caused a significant decrease in the frequency of the proximal region and fully inhibited the stimulating action of catecholamines, indicating that this stimulation was mediated by alpha-adrenoceptors. The myogenic natu...Continue Reading


Dec 1, 1975·European Journal of Pharmacology·N Longrigg
May 15, 1978·Experientia·C E ConstantinouM Mensah-Dwumah
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·M Del Tacca
Aug 19, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·O Reiner, J M Marshall
Mar 15, 1973·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Tomita, H Watanabe
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·M Del TaccaA Crema
Nov 6, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·W TuganowskiK Korczak
Aug 1, 1974·British Journal of Urology·N Longrigg
Jul 6, 1973·Pflügers Archiv : European journal of physiology·K Golenhofen, J Hannappel
Apr 4, 1974·Pflügers Archiv : European journal of physiology·J Hannappel, K Golenhofen
Jan 1, 1972·Pflügers Archiv : European journal of physiology·K Golenhofen, E Lammel
Oct 1, 1972·British Journal of Urology·J A Gosling, J S Dixon
Sep 1, 1971·European Journal of Pharmacology·J A Gosling, A N Waas

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