PMID: 6408665Jan 1, 1983Paper

The effects of drugs on the discrimination of color following a variable delay period: a signal detection analysis

Psychopharmacology
E B Nielsen, J B Appel

Abstract

Six pigeons were trained in a chamber with three response keys. Following an observing response on the center key, either colored or noncolored (white) lights were projected on that key. A second center key observing response provided an opportunity to respond on one of the side keys, appropriate to the stimuli presented, to obtain food; responding on the incorrect side produced a 30-s time-out. A delay period of varying duration with no stimuli followed stimulus presentation; the length of the delay was determined 'on-line', such that performance would be maintained at about 80% correct. Lysergic acid diethylamide (LSD, 0.04-0.2 mg/kg) had no significant effect on the accuracy of the discrimination (overall percent correct responses), even at doses that produced cessation of responding in some animals. Amphetamine (1-4 mg/kg) and morphine (0.5-4 mg/kg) decreased accuracy by decreasing sensitivity (A') and had little effect on reaction time. Haloperidol (0.5-2 mg/kg) had no significant effect on any measure of performance. None of the drugs altered response bias (B").

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Citations

Jan 1, 1988·Experimental Brain Research·J M WalkerH C Hughes
Jan 1, 1993·Psychopharmacology·D V Bradley, P M Blough
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·D M Thompson, J M Moerschbaecher
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·I WeinerO Ben-Shahar
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·I WeinerJ Feldon
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·M J Picker, C A Massie
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·M J PickerL A Dykstra
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·G R WengerD W Wright
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·R D HienzJ V Brady
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·D L FrederickM G Paule
Sep 1, 1984·Pharmacology, Biochemistry, and Behavior·D M Thompson, J M Moerschbaecher

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