The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle.

European Journal of Applied Physiology
Keita KanzakiMasanobu Wada

Abstract

The present study investigated the effects of eccentric muscle contractions (ECC) on the content of myofibrillar proteins (my-proteins) and the catalytic activity of myofibrillar ATPase (my-ATPase) in skeletal muscles. Rat extensor digitorum longus and tibialis anterior muscles were exposed to 200-repeated ECC or isometric contractions (ISC) and used for measures of force output and for biochemical analyses, respectively. Whereas in ISC-treated muscles, full restoration of tetanic force was attained after 2 days of recovery, force developed by ECC-treated muscles remained depressed (P < 0.05) after 6 days. The total my-protein content and the relative content of myosin heavy chain (MHC) in total my-proteins were unaltered during 4 days of recovery after ECC, but fell (P < 0.05) to 55.9 and 63.4% after 6 days of recovery, respectively. my-ATPase activity expressed on a my-protein weight basis was unaltered immediately after ECC. However, it decreased (P < 0.05) to 75.3, 45.3, and 49.3% after 2, 4 and 6 days of recovery, respectively. Total maximal calpain activity measured at 5 mM Ca(2+) was significantly augmented (P < 0.05) after 2 days of recovery, reaching a level of threefold higher after 6 days. These alterations were spec...Continue Reading

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Citations

Feb 22, 2014·Journal of Muscle Research and Cell Motility·Keita KanzakiMasanobu Wada
Dec 3, 2014·Scandinavian Journal of Medicine & Science in Sports·G CarmonaJ A Cadefau
Feb 25, 2011·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Julien GondinDavid Bendahan
Nov 22, 2014·Molecular Endocrinology·Alessia FratiElisabetta Meacci
Aug 30, 2014·Journal of Applied Physiology·Gerald S SupinskiLeigh Ann Callahan

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