The effects of ecstasy on liver function tests, blood glucose, and lipids profile of male rats

International Journal of High Risk Behaviors & Addiction
Mohammad Reza Shahraki, Mahdieh Irani

Abstract

Ecstasy is used to improve mood and cordiality; however, based on some reports, it is neurotoxic to human users. Because of the euphoria induced by MDMA (3,4-methylenedioxymethamphetamine) on the users, its consumption is increasing in almost all countries. This study was carried out to determine the effects of ecstasy administration in rats' blood sugar, lipids profile, and liver function tests. The experiment was performed using 50 mature Wistar-Albino male rats. The rats were divided into five groups (n = 10). Sham control group (A), received tap water and ordinary rodent diet. The control (B) was administered saline but tests group C, D1, and D2 received single dose and multiple doses of MDMA, respectively. After experimental period, animals were deeply anesthetized by diethyl ether, sacrificed and the blood samples were collected for the evaluation of blood glucose, serum lipid and aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALK-P). Data were expressed as mean ± SD and statistical difference was considered significant at P < 0.05. In C group, the values of blood sugar (193.8 ± 11.6 mg/dL), low density lipoprotein (LDL) (19.2 ± 7.9 mg/dL), and cholesterol (76.1 ± 10.6 mg/dL), were sig...Continue Reading

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