PMID: 2488013Jan 1, 1989Paper

The effects of endotoxin, glucocorticoids and prostaglandin metabolism in the rabbit iris

Lens and Eye Toxicity Research
J F RecasensK Green

Abstract

Superoxide dismutase activity (SOD) was measured in the irides of control animals (n = 16) and 24 hours after the intravitreal administration of endotoxin (n = 12). Nearly a twofold increase in SOD was noted in the endotoxin-treated animals (p less than 0.001). In order to assess the induction of SOD while protecting against the inflammatory process, topical dexamethasone (dex) was administered t.i.d. for 2 days before and 1 day after endotoxin (n = 6). Dex prevented the conjunctival hyperemia, vascular injection and iritis seen with endotoxin treatment alone and blocked the induction of SOD. A similar medrysone (med) application (n = 4) failed to prevent the visible signs of ocular inflammation yet also blocked the elevation of SOD. Pretreatment with either of the cyclooxygenase inhibitors, indomethacin (n = 4) or aspirin (n = 7), failed to block the induction in SOD (p less than 0.001 and p less than 0.01, respectively). However, the induction of SOD was prevented by the phospholipase A2 inhibitor, quinacrine, and the lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA). The data indicate that a product of the lipoxygenase pathway may be mediating the induction of SOD seen with endotoxin-induced ocular inflammation.

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here