The effects of endurance training in persons with a hereditary myosin myopathy

Acta Neurologica Scandinavica
K S SunnerhagenA Oldfors

Abstract

To evaluate muscle performance and its consequences in eight individuals with a hereditary myopathy and the effects of an 8-week endurance training program. Handgrip, muscle strength and endurance and oxygen consumption by breath-by-breath analysis during a stepless bicycle ergonometer test were evaluated. Walking, balance test and activities of daily living (ADL) were assessed, and a questionnaire for activity level and perceived symptoms was used. The design was a before-after trial in comparison with data from a control population, bicycling at 70% of maximal workload, 30 min/day, 5 days/week for 8 weeks. The subjects were weaker than age-matched controls. After training, the peak watt increased by almost 20% (P < 0.05). Muscle strength (flexion/extension) and isometric endurance (40% of maximum at 60 degrees ) did not change significantly. The average self-selected walking speed increased significantly (P < 0.05) from 1.25 to 1.45 m/s. Compliance was excellent and no serious adverse events occurred. Endurance training seems to function for this myopathy.

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Citations

Aug 25, 2012·Acta Neuropathologica·Homa Tajsharghi, Anders Oldfors
Oct 30, 2007·Archives of Physical Medicine and Rehabilitation·Edith H CupRob A Oostendorp
Jul 10, 2013·The Cochrane Database of Systematic Reviews·Nicoline B M VoetAlexander C H Geurts
Dec 7, 2019·The Cochrane Database of Systematic Reviews·Nicoline Bm VoetAlexander Ch Geurts
Nov 27, 2021·Expert Review of Cardiovascular Therapy·Gabriela Barroso de Queiroz DavoliTim Takken

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