PMID: 2105390Jan 1, 1990Paper

The effects of enteral stimulation on gallbladder bile during total parenteral nutrition in the neonatal piglet

Journal of Pediatric Surgery
I T CohenM P Hirsh

Abstract

The neonatal piglet is a satisfactory model for the human neonate requiring total parenteral nutrition (TPN). Bile status and subsequent liver and gallbladder dysfunction have long been documented as serious complications of long-term TPN. The purpose of this study was to determine whether small amounts of enteral formula during TPN will maintain normal bile appearance and composition. Thirty-one Hanford miniswine, 3 to 6 days old underwent surgery for the placement of central venous catheters. Two days postoperatively, the animals were separated into three groups, according to dietary regimens. Group 1 (n = 10), the control group, received pig formula (SPF-lac) orally (200 cal/kg/d); group 2 (n = 11), was maintained on TPN (180 cal/kg/d) with an enteral supplement of SPF-lac (20 cal/kg/d); group 3 (n = 10), was maintained on TPN only (200 cal/kg/d). The TPN formula consisted of 35 g/kg/d of glucose, 10 g/kg/d of protein, and 3 g/kg/d of lipid. The animals were maintained on these diets for 6 weeks. At necropsy, gallbladder with bile was weighed and bile volume and appearance was recorded. Chemical analyses was performed on 26 bile samples. Gallbladder weight was significantly decreased in groups 2 and 3 compared with group 1 (...Continue Reading

References

Jan 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·R J Merritt
Mar 1, 1987·Pediatric Annals·N F Sheard, R E Kleinman
Jan 1, 1985·Journal of the American College of Nutrition·C C Roy, D C Belli
Mar 4, 1968·JAMA : the Journal of the American Medical Association·D W Wilmore, S J Dudrick

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Citations

Sep 1, 1996·Digestive Diseases and Sciences·D R DuerksenM T Clandinin
Nov 3, 2010·Journal of the American Dietetic Association·Catherine J KleinLouis Scavo
Apr 9, 2001·Clinics in Liver Disease·I S SandhuG T Everson
Jun 1, 1995·Journal of the American College of Nutrition·E R Briones, F L Iber
Mar 26, 2003·European Journal of Gastroenterology & Hepatology·Michael F ByrneAiden McCormack
Feb 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F E Murray, C J Hawkey
Oct 7, 2004·Clinics in Liver Disease·V Kwan, J George

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