The effects of environmental hypoxia on substrate utilisation during exercise: a meta-analysis

Journal of the International Society of Sports Nutrition
Alex GriffithsJohn P O'Hara

Abstract

A better understanding of hypoxia-induced changes in substrate utilisation can facilitate the development of nutritional strategies for mountaineers, military personnel and athletes during exposure to altitude. However, reported metabolic responses are currently divergent. As such, this systematic review and meta-analysis aims to determine the changes in substrate utilisation during exercise in hypoxia compared with normoxia and identify study characteristics responsible for the heterogeneity in findings. A total of six databases (PubMed, the Cochrane Library, MEDLINE, SPORTDiscus, PsychINFO, and CINAHL via EBSCOhost) were searched for published original studies, conference proceedings, abstracts, dissertations and theses. Studies were included if they evaluated respiratory exchange ratio (RER) and/or carbohydrate or fat oxidation during steady state exercise matched for relative intensities in normoxia and hypoxia (normobaric or hypobaric). A random-effects meta-analysis was performed on outcome variables. Meta-regression analysis was performed to investigate potential sources of heterogeneity. In total, 18 studies were included in the meta-analysis. There was no significant change in RER during exercise matched for relative e...Continue Reading

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Citations

Jun 18, 2019·Medicine and Science in Sports and Exercise·John P O'HaraRoderick F G J King
Jul 12, 2020·Physiological Reports·Daichi SumiKazushige Goto
Jul 5, 2019·European Journal of Applied Physiology·Alex GriffithsJohn P O'Hara
Jul 14, 2019·Journal of the International Society of Sports Nutrition·Andrew J YoungStefan M Pasiakos
Dec 21, 2019·Journal of the International Society of Sports Nutrition·Alex GriffithsJohn P O'Hara
Oct 13, 2020·Medicine and Science in Sports and Exercise·Alex GriffithsJohn P O'Hara
Jul 21, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Stefan M PasiakosLee M Margolis

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Methods Mentioned

BETA
acylation

Software Mentioned

Comprehensive Meta - Analysis
Review Manager ( RevMan )
EBSCO
DigitizeIt

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