The effects of environmentally relevant mixtures of estrogens on Japanese medaka (Oryzias latipes) reproduction

Aquatic Toxicology
James A JukoskyJames C Leiter

Abstract

Wastewater effluent contains a variety of estrogenic compounds that vary in potency, but each of which contributes to the overall estrogenicity of the effluent. We hypothesized that the effects of mixtures of estrogens on reproduction in pair breeding medaka (Oryzias latipes) could be predicted by their relative estrogenicity. Relative estrogenicity was defined by the ability of estrogenic compounds to induce vitellogenesis in various species of male fish. We exposed reproducing pairs of medaka to mixtures of the environmental estrogens nonylphenol (NP), 17alpha-ethinylestradiol (EE(2)), and natural 17beta-estradiol (E(2)), as well as treatments of equivalent estrogenicity that were composed of E(2) alone. Reproducing medaka exposed to mixtures of estrogenic compounds and equipotent treatments of estradiol alone had very similar responses in mortality and reproduction (fecundity, number of spawns). However, mixtures of NP, E(2), and EE(2) elicited lower vitellogenic induction than equipotent concentrations of E(2) alone. Therefore, relative estrogenicity was a good model for predicting some, but not all, reproductive responses, and simple additive mixture models may not predict all relevant physiological responses.

References

Mar 29, 2002·Environmental Science & Technology·Chad R HammerschmidtRonald G Rada
Jul 24, 2002·Biology of Reproduction·Susan JoblingJ P Sumpter
Aug 3, 2002·Environmental Toxicology and Chemistry·Masanori SekiKunio Kobayashi
Apr 23, 2003·Ecotoxicology and Environmental Safety·S M Billiard, R A Khan
Sep 12, 2003·Environmental Science & Technology·Janet Pelley
Nov 1, 2003·Environmental Toxicology and Chemistry·Edward P KolodziejDavid L Sedlak
May 3, 2005·The Science of the Total Environment·Lesley J Mills, Clinton Chichester
Jun 3, 2005·Environmental Health Perspectives·Jayne V BrianJohn P Sumpter

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Citations

Jul 29, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Natallia ShvedManfred Reinecke
Nov 26, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yuanxiang JinZhengwei Fu
Jan 27, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Karen P MaruskaAllen F Mensinger
Apr 11, 2012·Environmental Toxicology and Chemistry·Daniel J CaldwellJohn P Sumpter
May 7, 2015·Critical Reviews in Toxicology·Matthew D OverturfDouglas A Holdway
Jan 20, 2018·Journal of Biochemical and Molecular Toxicology·Madeha A RiadMohamed M Badawy
Feb 3, 2009·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Kiril D HristovskiPaul K Westerhoff
Nov 25, 2016·Reviews on Environmental Health·Emad Nazari, Fatihah Suja
Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·André PereiraAngelina Pena
Sep 6, 2020·The Science of the Total Environment·Prangya R RoutRao Y Surampalli

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