The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
R C BlockS Georas

Abstract

Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis.

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Citations

Sep 29, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert C BlockSteve Georas
Aug 8, 2012·Biochimica Et Biophysica Acta·Ioanna SevastouVassilis Aidinis
Nov 26, 2015·Medical Hypotheses·O A Akerele, S K Cheema
Apr 7, 2018·Biomarker Insights·Giovana Colozza MecattiPatricia de Oliveira Carvalho
Mar 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason EmoSteve N Georas
Jan 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara Knowlden, Steve N Georas
Feb 8, 2018·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Gregory C ShearerJohn W Newman
Jan 7, 2018·Molecular Aspects of Medicine·R J Scott LacombeRichard P Bazinet

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