PMID: 6159487Sep 1, 1980Paper

The effects of epidural anesthesia on the urethral closure pressure profile in patients with prostatic enlargement

The Journal of Urology
R A AppellE J McGuire

Abstract

In 10 patients with obstructive manifestations of prostatic enlargement the urethral closure pressure profile was observed before and after the effective blockade of thoracolumbar sympathetic outflow by epidural anesthesia. While epidural anesthesia significantly decreased urethral closure pressure considerable profile responses still remained in these patients. This fact suggests that the bulk of the prostatic tissue is responsible for the bladder outlet obstruction, since urethral closure pressure persists despite urethral smooth and skeletal muscular relaxation as a result of epidural anesthesia. After transurethral resection of the prostatic tissue in these patients the urethral closure pressure did decrease to zero. The result of the prostatic resection is to decrease the urethral closure pressure and, thereby, increase the efficiency of voiding.

References

Dec 1, 1975·British Journal of Urology·M A GhoneimJ G Susset
Dec 1, 1973·British Journal of Urology·R T WarwickJ Weir
Dec 1, 1973·The Journal of Urology·R J Krane, C A Olsson
Apr 1, 1969·British Journal of Urology·M Brown, J E Wickham

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Citations

Oct 1, 1981·Postgraduate Medical Journal·R A Appell
Apr 26, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Patrick Y WuethrichFiona C Burkhard
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Oct 3, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Th Jimmy YangS Alan McNeill
Apr 1, 1985·Acta Anaesthesiologica Scandinavica·K AxelssonB Widman
Jan 27, 1998·British Journal of Obstetrics and Gynaecology·G HaeuslerH Koelbl
Mar 19, 2008·Expert Opinion on Pharmacotherapy·Vinod H Nargund, Alistair D R Grey
May 13, 2010·Anesthesiology·Patrick Y WuethrichFiona C Burkhard
Jul 7, 2007·Nature Clinical Practice. Urology·Karl-Erik Andersson, Christian Gratzke

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