The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task

Psychopharmacology
E J RoseK P Ebmeier

Abstract

Psychotropic medication affects cognition and brain function, making it a potential confounder in functional neuroimaging studies of psychiatric patients. To determine whether the sub-acute administration of an antidepressant (escitalopram) would induce differences in cognitive performance and associated brain function, which could be observed within the normal power of a functional imaging study. Healthy adults (N=10) received a short course of escitalopram (10 mg/day for 7 days). Participants performed a parametric working memory (WM) task during BOLD fMRI, both while medication-free and after medication. To control for order effects, the medication-free examination was completed by half the subjects before starting medication and by the other half at least one week after medication. Escitalopram had no significant effect on WM accuracy or reaction time. Preliminary analysis of the imaging data revealed no significant (p(corrected)<0.05) differences in memory-load-dependent activation between conditions. However, small volume correction analysis of regions that were significant prior to correction for multiple comparisons highlighted between condition differences in regions likely to be susceptible to antidepressant effects (...Continue Reading

References

Sep 1, 1978·The British Journal of Social and Clinical Psychology·C MackayT Lazzerini
Mar 1, 1991·Journal of Clinical and Experimental Neuropsychology·D WillshireM Prior
Jan 1, 1988·European Journal of Clinical Pharmacology·I Hindmarch, J Z Bhatti
Oct 1, 1987·Journal of Clinical Psychopharmacology·J M GormanD F Klein
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·I Amado-BoccaraH Lôo
Jan 1, 1995·International Clinical Psychopharmacology·I Hindmarch
Sep 1, 1993·Electroencephalography and Clinical Neurophysiology·A Gevins, B Cutillo
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·D B FairweatherI Hindmarch
Sep 2, 1999·Harvard Review of Psychiatry·P S Masand, S Gupta
Jul 27, 2000·Human Brain Mapping·J L LancasterP T Fox
Aug 20, 2002·Psychopharmacology·Catherine J HarmerGuy M Goodwin
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Wayne C DrevetsMarcus E Raichle
Dec 31, 2002·The American Journal of Psychiatry·Richard J DavidsonNed H Kalin
Feb 4, 2003·The American Journal of Psychiatry·Julia DaviesLyn S Pilowsky
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cristina M Del-BenIan M Anderson
May 13, 2005·Psychopharmacology·S McKieJ F W Deakin
Jun 14, 2005·Biological Psychiatry·Sally E Shaywitz, Bennett A Shaywitz
Dec 21, 2005·Journal of Affective Disorders·E J Rose, K P Ebmeier

❮ Previous
Next ❯

Citations

Dec 7, 2007·Psychopharmacology·Estibaliz ArceMartin P Paulus
Mar 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·David ZillesOliver Gruber
Oct 23, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annette Beatrix BrühlUwe Herwig
Nov 26, 2010·Psychopharmacology·Sakthivel SekarMohammed Shoaib
May 9, 2012·The Journal of Pain : Official Journal of the American Pain Society·Dieuwke S VeldhuijzenJoukje M Oosterman
Oct 1, 2010·Psychiatry Research·Victoria GradinJohn Douglas Steele
Jul 16, 2008·Neuropharmacology·I M AndersonJ F W Deakin
Sep 1, 2015·Behavioural Brain Research·Christy A OlsonCary R Savage
May 10, 2015·La Presse médicale·Anne-Sophie Lemaire-HurtelAlain G Verstraete
Feb 1, 2011·Neuropharmacology·Alfredo MenesesCarlos Castillo
Jan 3, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M L J SchouwL Reneman
Dec 9, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marcella BellaniPaolo Brambilla
Jul 5, 2011·Journal of Affective Disorders·Julian G Simmons, Nicholas B Allen
Jun 24, 2009·The International Journal of Neuropsychopharmacology·Alan N SimmonsMartin P Paulus
Oct 28, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Beomwoo NamDoug Hyun Han
Nov 2, 2018·Psychopharmacology·Eldad YechiamMili Bar-Shaked
Jul 1, 2010·Expert Review of Clinical Pharmacology·Ulrich RablLukas Pezawas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Cristina M Del-BenIan M Anderson
Current Pharmaceutical Design
Jeroen A J SchmittWim J Riedel
© 2021 Meta ULC. All rights reserved