PMID: 6537682Jan 1, 1984Paper

The effects of essential fatty acid deficiency on pulmonary alveolar macrophage function

Transactions of the American Clinical and Climatological Association
J A BalintN W Kaye

Abstract

Male rats were maintained for periods of up to 16 weeks on a fat free diet which was supplemented with either 4% tripalmitin (essential fatty acid [EFA] deficient) or with 4% safflower oil (SAFF, control). Pulmonary alveolar macrophages (PAM) were obtained by lung lavage. PAM from EFA deficient rats had reduced phagocytic activity and capacity. Intracellular killing of ingested yeast was also reduced by EFA deficiency. The activity of acid phosphatase, beta-glucuronidase and cathepsin D from PAM was not altered by dietary treatment. Transmission electron microscopy failed to show any consistent morphologic differences between PAM from EFA deficient and SAFF animals, but did confirm the decreased phagocytosis by PAM from EFA deficient rats. However, scanning electron microscopy did show loss of pseudopodia in PAM from EFA deficient rats. EFA deficiency was demonstrated by analyzing the methyl esters of the fatty aids from the total lipid extract of PAM. The arachidonate content was decreased while the eicosatrienoate content was increased in PAM derived from rats fed the EFA deficient diet. In an effort to elucidate further the mechanism of action of EFA deficiency in impairing phagocytosis by PAM, inhibitors of various reaction...Continue Reading

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