The effects of estrogen receptor α polymorphism on the prevalence of symptomatic temporomandibular disorders

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Bum-Soo KimJihyun Bae

Abstract

The aim of this study is to identify any association between variants of the polymorphic estrogen receptor gene and various symptoms of temporomandibular disorder (TMD) including pain in the temporomandibular joint and masticatory muscles, joint crepitus, limited range of jaw movement, and bone changes in the condylar head. Seventy-four patients with TMD were selected according to the Research Diagnostic Criteria for TMD for the study group. Sixty-four patients without TMD were selected as the control group. Genomic DNA was extracted from the epithelial layer of buccal mucosa. After amplification by polymerase chain reaction, direct haplotyping was undertaken to study the restriction fragment length polymorphism of PvuII and XbaI for the α estrogen receptor. Genomic prevalences in each of the symptom categories were analyzed by use of the χ(2) test. The haplotypes PX, Px, and px constituted 23.0%, 18.9%, and 58.1%, respectively, of the total α estrogen receptor alleles in the study group. The haplotype Px was found to be relatively more prevalent in subjects who had mouth opening limitation, and the haplotype PX was more prevalent in those patients with condylar head bone changes. However, neither of these observations carried ...Continue Reading

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Citations

May 28, 2011·BMC Medical Genetics·Angel Aneiros-GuerreroArmando Reyes-Engel
Dec 10, 2013·Medicina oral, patología oral y cirugía bucal·Bruno-Gama MagalhãesArnaldo-de-França Caldas-Júnior
Dec 7, 2013·The Journal of Pain : Official Journal of the American Pain Society·Shad B SmithLuda Diatchenko
Sep 16, 2014·Cranio : the Journal of Craniomandibular Practice·Marcello Melis, Massimilino Di Giosia
Oct 27, 2016·Neuroscience·Katerina Zorina-LichtenwalterL Diatchenko
Aug 16, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Romain NicotJames J Sciote
May 13, 2017·Journal of Oral Rehabilitation·D V da CunhaA A Pereira
Jan 29, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Young-Kyun Kim
Jan 29, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Ji-Young LeePil-Young Yun
Dec 20, 2014·Journal of Oral Rehabilitation·C M Visscher, F Lobbezoo
Oct 28, 2019·Acta Odontologica Scandinavica·Erika Calvano KüchlerRafaela Scariot

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