The effects of ethanol on spatial and nonspatial memory in adolescent and adult rats studied using an appetitive paradigm

Annals of the New York Academy of Sciences
P Rajendran, L P Spear

Abstract

Adolescent rats have been reported to be less sensitive than adults to many acute ethanol effects, including ethanol-induced sedation and motor impairment, but conversely more sensitive to ethanol-induced disruptions in spatial memory in a Morris water maze (Markwiese et al., 1998). The present study examined adolescent and adult rats trained for 6 days under spatial or nonspatial versions of a presumably less stressful sand box maze. Moderately food-deprived animals were given 0, 0.5, or 1.5 g/kg ethanol intraperitoneally 30 min before training each day, but were tested without ethanol or reinforcer on test day. Spatial acquisition was impaired by 1.5 g/kg in adults but not adolescents, with no ethanol impairment on the nonspatial task at either age. These results are opposite the ontogenetic profile reported by Markwiese et al., (1998) and may reflect differential activation of prefrontal cortex or other stress-sensitive forebrain regions by the two tasks across age.

References

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Citations

Dec 25, 2007·Psychopharmacology·Rebekah A StevensonClyde W Hodge
Jun 24, 2009·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Sep 5, 2012·Alcohol·Luis M García-Moreno, Jose M Cimadevilla
Feb 17, 2005·Alcoholism, Clinical and Experimental Research·Peter M MontiFulton T Crews
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Melanie L SchwandtJames D Higley
Jan 10, 2013·Alcoholism, Clinical and Experimental Research·M Jerry WrightMichael A Taffe
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Candice E Van SkikeDouglas B Matthews
Feb 24, 2015·Alcoholism, Clinical and Experimental Research·James M Doherty, Rueben A Gonzales
Jun 22, 2012·Behavioral and Brain Functions : BBF·Antonio Vidal-InferMarta Rodríguez-Arias
Jul 6, 2015·Physiology & Behavior·Mauro CeccantiMarco Fiore
Apr 7, 2015·Pharmacology, Biochemistry, and Behavior·Adelle NovierDouglas B Matthews
Jun 27, 2014·The International Journal of Neuropsychopharmacology·Amul J SakharkarSubhash C Pandey
Sep 11, 2014·Behavioural Brain Research·Sara N Burke, Carol A Barnes
Apr 25, 2009·Alcoholism, Clinical and Experimental Research·Shelly D DickinsonDean Y Charles

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