The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

Pharmacology, Biochemistry, and Behavior
Renee ClaytorMichael A Nader

Abstract

The dopamine D3 receptor is mainly expressed in regions of the brain associated with the limbic system. D3 receptor blockade may antagonize cocaine reinforcement while producing less severe extrapyramidal side effects than blockade of D2 receptors. The purpose of the present studies was to evaluate the effects of a selective D3 receptor antagonist and a non-selective D2/D3 receptor antagonist on food- and cocaine-maintained responding under two schedules of cocaine self-administration. Adult male rhesus monkeys were trained to respond under multiple schedules of food (1.0 g pellets) and cocaine (0.01-0.3 mg/kg/injection) presentation. In one experiment (n=4), the schedule was a fixed-interval (FI) 3-min and a second study (n=6) was conducted using a second-order fixed-ratio 5 (FI 6-min:S) schedule. The D3 antagonist PNU 99194-A (0.3-3.0 mg/kg), which is 14-fold selective for D3 relative to D2 receptors, or the D2/D3 antagonist eticlopride (0.001-0.03 mg/kg) was administered immediately prior to the experimental session for at least 5 consecutive sessions. Under the multiple FI 3-min schedule of food and cocaine presentation, PNU 99194-A and eticlopride decreased food- and cocaine-maintained responding in a dose-dependent manner...Continue Reading

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Citations

Sep 16, 2008·Neurotoxicity Research·R J Beninger, T J Banasikowski
Oct 18, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack Bergman
Jan 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloStephen J Kohut
Nov 14, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul W Czoty, Michael A Nader
May 6, 2017·The Journal of Pharmacology and Experimental Therapeutics·Morgane ThomsenS Barak Caine
Sep 11, 2013·The Journal of Pharmacology and Experimental Therapeutics·Timothy H C CheungJanet L Neisewander

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