The effects of exchange transfusion for prevention of complications during pregnancy of sickle hemoglobin C disease patients

Transfusion
Bruno Deltreggia BenitesSara Teresinha Olalla Saad

Abstract

Pregnancy represents a challenge for women with sickle cell disease (SCD), with higher rates of both maternal and fetal complications. The aim of this study was to evaluate the impact of prophylactic transfusion support administered specifically to pregnant women with sickle hemoglobin C disease. Patients were divided into two groups according to the type of transfusion support received: 10 women received prophylactic erythrocytapheresis or manual exchange transfusion at 28 weeks of gestation, and 14 received transfusions only on demand, due to acute complications, or received no transfusions at all. Our results indicated higher frequencies of SCD-related complications in the group that did not receive prophylactic transfusion support (35.7% vs. only 10% in the erythrocytapheresis group). Furthermore, these complications were more severe in this group and included all cases of acute chest syndrome. A significant difference was observed concerning gestational age at birth (38.7 weeks in the transfusion group vs. 34.4 weeks, p = 0.037), with a higher frequency of preterm births in the nontransfused group (69.23% vs. 30% in the transfusion group). We demonstrated a clear reduction of unfavorable outcomes in patients receiving prop...Continue Reading

References

Jul 1, 1978·The Journal of Pediatrics·H CapurroR Caldeyro-Barcia
Mar 1, 1992·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F O DareO B Faasuba
Jul 1, 1986·British Journal of Obstetrics and Gynaecology·D PoddarG R Serjeant
Feb 1, 1983·British Journal of Obstetrics and Gynaecology·S M TuckJ M White
Feb 15, 2001·The New England Journal of Medicine·B M CaseyK J Leveno
Jun 24, 2003·Blood Reviews·Ronald L NagelMartin H Steinberg
Oct 12, 2004·Lancet·Marie J Stuart, Ronald L Nagel
Nov 25, 2004·Hematology·George R BuchananMartin H Steinberg
Aug 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Graham R SerjeantMinerva Thame
Mar 28, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K E RajabA A Ajami
Dec 26, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S C GilliS T Saad
Jul 30, 2009·Acta Obstetricia Et Gynecologica Scandinavica·Elizabeth GrossettiMichel Dreyfus
Sep 18, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C NgôB Haddad

❮ Previous
Next ❯

Citations

Dec 17, 2016·British Journal of Haematology·Lydia H PeckerLori Luchtman-Jones
Jul 7, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ramona MontironiJacques C Jani
Nov 20, 2016·British Journal of Haematology·Bernard A DavisUNKNOWN British Society for Haematology
Dec 4, 2016·Hematology·Jo Howard
Apr 19, 2018·Case Reports in Critical Care·Jefferson ChambersSubramanyam Chittivelu
Aug 20, 2021·British Journal of Haematology·Eugene Oteng-NtimUNKNOWN British Society for Haematology Guideline

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
S C GilliS T Saad
The New England Journal of Medicine
J C Morrison, F S Morrison
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
Françoise DrissG Tchernia
New York State Journal of Medicine
D E Murdoch, B N Nathanson
© 2021 Meta ULC. All rights reserved