The effects of excitotoxic lesion of the medial prefrontal cortex on latent inhibition, prepulse inhibition, food hoarding, elevated plus maze, active avoidance and locomotor activity in the rat

Neuroscience
L LacroixJ Feldon

Abstract

Latent inhibition is a measure of retarded conditioning to a previously presented nonreinforced stimulus that is impaired in schizophrenic patients and in rats treated with amphetamine. In terms of neural substrates, latent inhibition depends on the integrity of the nucleus accumbens and the inputs to this structure from the hippocampal formation and adjacent cortical areas. Since another major source of input to the nucleus accumbens is the medial prefrontal cortex, and there are numerous demonstrations that manipulations of this region can modify ventral striatal dopamine, we investigated the effects of N-methyl-D-aspartate lesion to the medial prefrontal cortex on latent inhibition, assessed in an off-baseline conditioned emotional response procedure in rats licking for water. In addition, the effects of the medial prefrontal cortex lesion were assessed on a battery of tasks potentially sensitive to medial prefrontal cortex damage, including spontaneous and amphetamine-induced activity, elevated plus maze exploration, food hoarding, prepulse inhibition, and active avoidance. The lesion decreased hoarding behaviour and increased spontaneous exploratory activity in the open field, while exerting only mild effects on amphetamin...Continue Reading

References

Jan 1, 1979·Journal of Neuroscience Research·A W Toga, H A Burton
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·G E Jaskiw, D R Weinberger
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·J FeldonI Weiner
Aug 15, 1991·Biological Psychiatry·J G CsernanskyW O Faustman
Nov 1, 1990·Psychological Bulletin·I Weiner
Jan 1, 1990·Schizophrenia Bulletin·T W Robbins
Oct 1, 1988·The Journal of Nervous and Mental Disease·I BaruchJ A Gray
Jan 1, 1987·Psychopharmacology·I Weiner, J Feldon
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·I WeinerJ Feldon
Apr 1, 1988·Biological Psychiatry·G W ChristisonC D Kilts
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Aug 1, 1985·Archives of General Psychiatry·B BogertsR Schönfeldt-Bausch
Oct 1, 1974·Journal of Comparative and Physiological Psychology·B KolbR K Singh
Aug 1, 1974·Journal of Comparative and Physiological Psychology·A J NonnemanB E Kolb
Jun 1, 1973·Psychological Bulletin·R E Lubow
Dec 1, 1969·Journal of Comparative and Physiological Psychology·J E AckilG P Frommer
Aug 1, 1981·Journal of Comparative and Physiological Psychology·A J Nonneman, J V Corwin
Mar 1, 1995·Biological Psychiatry·N R SwerdlowD L Braff
Feb 1, 1995·Trends in Pharmacological Sciences·G R Dawson, M D Tricklebank
Jan 1, 1995·Psychological Bulletin·R E Lubow, J C Gewirtz

❮ Previous
Next ❯

Citations

Jun 29, 2004·Behavioural Brain Research·Kerstin SchwabeMichael Koch
May 9, 2002·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Jun 6, 2002·Behavioural Brain Research·Laurent LacroixJoram Feldon
Mar 19, 2003·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Sep 10, 2003·Progress in Neurobiology·Tobias Bast, Joram Feldon
Nov 15, 2002·Brain Research Bulletin·Terence V Sewards, Mark A Sewards
May 14, 1999·Current Opinion in Neurobiology·P W Kalivas, M Nakamura
Sep 13, 2001·The European Journal of Neuroscience·K GuentherJ N Rawlins
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ilia N KaratsoreosBruce S McEwen
Jul 4, 2001·Neuroreport·R M DeaconJ N Rawlins
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael L Lehmann, Miles Herkenham
Jul 22, 2008·Biological Psychiatry·Mounira Banasr, Ronald S Duman
Feb 5, 2008·Behavioural Brain Research·Galina F Molodtsova
Apr 14, 2010·The European Journal of Neuroscience·David N GeorgeSimon Killcross

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.