The Effects of Exenatide and Metformin on Endothelial Function in Newly Diagnosed Type 2 Diabetes Mellitus Patients: A Case-Control Study

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Yanjin HuYuan Xu

Abstract

Exenatide is a new antidiabetic glucagon-like peptide-1 receptor agonist. In addition to its hypoglycemic effect, exenatide may have a potential protective benefit on vascular endothelial function. This study attempted to compare the effects of exenatide and traditional antidiabetic drug metformin treatment on endothelial function in overweight patients with type 2 diabetes. Ninety overweight patients with newly diagnosed type 2 diabetes were recruited; 45 patients received exenatide (Exe) treatment and 45 patients received metformin (Met) treatment for 12 weeks. The control groups included 37 overweight and 24 non-overweight individuals. The parameters of glucose and lipid metabolism and endothelial function were measured before and after treatment. Vascular endothelial dysfunction was measured by reactive hyperemia index. Newly diagnosed patients with type 2 diabetes had more serious vascular endothelial dysfunction than both overweight and normal-weight control groups. The levels of body mass index, glucose, HbA1c, homeostasis model assessment insulin resistance, and homeostasis model assessment β-cell function were improved significantly by both exenatide and metformin treatment. Both exenatide and metformin treatment can i...Continue Reading

References

Nov 24, 2012·Current Pharmaceutical Design·Serena Del TurcoAmalia Gastaldelli
Jan 12, 2013·Reviews in Endocrine & Metabolic Disorders·Ranganath Muniyappa, James R Sowers
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Mar 24, 2016·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Agostino Virdis
Apr 14, 2016·American Journal of Physiology. Endocrinology and Metabolism·Rui WeiTianpei Hong
Mar 20, 2018·Journal of UOEH·Keiichi TorimotoYoshiya Tanaka

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Citations

Feb 2, 2019·Aging and Disease·Tseng Chin-Hsiao
Jan 22, 2019·Current Medicinal Chemistry·Anastasios TentolourisNikolaos Tentolouris
Jun 4, 2020·International Journal of Molecular Sciences·Maria Cristina VinciGiulio Pompilio
Sep 12, 2018·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Carolina De CiuceisDamiano Rizzoni
Sep 23, 2018·International Journal of Molecular Sciences·Joseph ZhouLixin Li

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