The effects of exercise and diurnal variation on monocyte subsets and monocyte-platelet aggregates

European Journal of Clinical Investigation
E ShantsilaG Y H Lip

Abstract

Monocytes are important mediators in the pathophysiology of cardiovascular disease, but only scarce data are available on biological and methodological factors affecting their levels. Three monocyte subsets, CD14(++) CD16(-) CCR2+ (Mon1), CD14(++) CD16(+) CCR2(+) (Mon2), CD14(+) CD16(+) CCR2(-) (Mon3), and monocyte-platelet aggregates (MPAs) were analysed by flow cytometry. The effects of treadmill exercise were assessed on 12 healthy volunteers. Diurnal variation was evaluated in 16 healthy volunteers, and the effects of delayed blood processing were measured in 12 samples. Mon1 were increased when measured 15 min after exercise followed by a reduction at 1 h (P < 0·05 for both). MPAs were significantly reduced at 15 min and 1 h (P < 0·05 for both). There was significant diurnal variation in the numbers of Mon2, which were highest at 6 pm and lowest at 6 am. There were also significant diurnal variations in phagocytic activity of Mon1 and Mon2, which were highest at 12 pm and lowest at 12 am. Monocyte counts remained stable up to 2 h after venipuncture. MPAs were significantly increased at 2 h and increased further by 4 h after sampling. Monocyte subset Mon2 and monocyte phagocytic activity undergo significant diurnal variatio...Continue Reading

References

Aug 25, 1999·British Journal of Haematology·B JilmaO F Wagner
May 10, 2002·Clinical Cardiology·Uichi IkedaKazuyuki Shimada
Feb 20, 2007·Journal of the American College of Cardiology·Eduard ShantsilaGregory Y H Lip
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Mitsuaki HayashiMasakatsu Tezuka
Feb 12, 2008·Journal of the American College of Cardiology·Eduard ShantsilaGregory Y H Lip
Feb 29, 2008·Annual Review of Immunology·Natalya V SerbinaEric G Pamer
Aug 12, 2008·Thrombosis and Haemostasis·Janine M van GilsJaap Jan Zwaginga
Jan 10, 2009·Annual Review of Immunology·Cedric AuffrayFrederic Geissmann
Jul 4, 2009·Journal of the American College of Cardiology·Eduard Shantsila, Gregory Y H Lip
Jan 12, 2010·European Journal of Applied Physiology·Marta Oliveira, Michael Gleeson
Jul 16, 2010·Blood·Loems Ziegler-HeitbrockManfred B Lutz

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Citations

Nov 15, 2014·Hämostaseologie·M Hristov, G H Heine
Dec 18, 2012·European Journal of Clinical Investigation·Benjamin J WrigleyGregory Y H Lip
Oct 19, 2013·European Journal of Clinical Investigation·Anthony S JaipersadGregory Y H Lip
Mar 19, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Darío G FerrerGustavo A Chiabrando
Jul 25, 2015·Scandinavian Journal of Immunology·D WangL Yin
Jan 15, 2015·Mediators of Inflammation·Amaryllis H Van CraenenbroeckEmeline M Van Craenenbroeck
Nov 12, 2015·BioMed Research International·Stefan Heber, Ivo Volf
May 23, 2014·Journal of Thrombosis and Thrombolysis·Shan ZengYu-Ming Li
Jan 15, 2016·Medicine and Science in Sports and Exercise·Christof A LeichtNicolette C Bishop
Dec 24, 2018·Antioxidants·Ning Hong AwJorming Goh
Dec 4, 2019·Frontiers in Immunology·Amit A Patel, Simon Yona

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