The effects of exercise at high altitude on high-sensitivity cardiac troponin release and associated biventricular cardiac function

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Christopher John BoosDavid Richard Woods

Abstract

It has been consistently shown that heavy exercise leads to cardiac troponin (cTn) release and variable changes in post exercise cardiac function. This relationship has not been explored at increasing or significant high altitude (HA). This study assessed the effects of exercise at progressively increasing HA on high-sensitivity (hs)-cTnT levels and their relationship to biventricular cardiac function and severity of acute mountain sickness (AMS). Transthoracic echocardiograms, hs-cTnT levels and AMS scores were measured at rest at 1,300 m then repeated post exercise and 12 h later after progressive trekking to 3,440, 4,270 m and at 5,150 m (after trekking to 5,643 m) on 19 healthy subjects (age 35.4 ± years, 52.6 % males). There was a detectable increase (>5 ng/L) in post exercise hs-cTnT with exercise at HA which became significant at 5,150 m (5.84 % at 3,440 m, 5.2 % at 4,270 m and 56.3 % at 5,150 m; p = 0.0005). Compared with baseline, HA to 5,150 m led to a significant rise in post exercise Lake Louis AMS scores (p < 0.001) pulmonary artery systolic pressure (PASP) (23.7 ± 3.8 vs 37.9 ± 11.7 mmHg: p < 0.001), cardiac output (5.2 ± 1.2 vs 7.5 ± 1.3 l/min; p < 0.001) and a fall in SpO2 (96.1 ± vs 77.4 ± 12.0 %; p < 0.001). T...Continue Reading

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Citations

Mar 24, 2016·High Altitude Medicine & Biology·Christopher John BoosDavid Richard Woods
Oct 31, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tobias ZeusAmin Polzin
Oct 21, 2014·High Altitude Medicine & Biology·Adrian MellorDavid Woods
Jul 16, 2016·International Journal of Cardiology·T Gresslien, S Agewall
May 26, 2017·Journal of Human Hypertension·C J BoosJ O'Hara
Jun 22, 2018·PloS One·Christopher J BoosDavid R Woods

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