The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions.

Acta Histochemica Et Cytochemica
Guo WenLuo Xue-Gang

Abstract

Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not clear. The purpose of this study was to assess the effects of exercise-induced fatigue on the expression and activity of acetylcholinesterase at the neuromuscular junctions. The expression and activity of acetylcholinesterase at the gastrocnemius neuromuscular junctions was decreased transiently by exercise-induced fatigue and then gradually increased over 24 hr. The expression of acetylcholinesterase in the 24 hr recovery group returned to the level of the control (non-exercised) group, but the activity of acetylcholinesterase remained significantly lower. These data suggest that the decrease of acetylcholinesterase expression and activity may be involved in the production and/or maintenance of exercise-induced fatigue.

References

Jul 1, 1993·Progress in Neurobiology·J MassouliéF M Vallette
Feb 9, 2000·Annals of Neurology·K OhnoI Akiguchi
Apr 3, 2001·Nature Reviews. Neuroscience·H Soreq, S Seidman
Sep 19, 2001·European Journal of Applied Physiology·R LepersJ Brisswalter
Dec 26, 2001·Journal of Neuroscience Research·Peter Pregelj, Janez Sketelj
Mar 16, 2002·Journal of Applied Physiology·Romuald LepersGuillaume Y Millet
Jul 20, 2002·Brain Research. Developmental Brain Research·Ellen G DuysenOksana Lockridge
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS
Aug 3, 2005·Journal of Neural Transmission·J SchumacherG Schulte-Körne
May 23, 2006·Journal of Applied Physiology·S C Gandevia, J L Taylor
Jun 13, 2006·Neuroscience Research·E MouiselA Ferry
Jan 16, 2007·Medicine and Science in Sports and Exercise·Frédéric GarrandesPatrick Legros
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter PregeljJanez Sketelj
Jan 31, 2009·Acta Histochemica Et Cytochemica·Chen DanLuo Xue-Gang
May 1, 2005·Environmental Toxicology and Pharmacology·Carey PopeJing Liu

❮ Previous
Next ❯

Citations

Feb 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Juliano M VieiraRoselia M Spanevello
Dec 5, 2019·Anais Da Academia Brasileira De Ciências·Lijuan HouDecai Qiao

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme linked immunoabsorbent assay

Software Mentioned

SPSS
SigmaStat

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.